ChemicalBook--->CAS DataBase List--->102-76-1

102-76-1

102-76-1 Structure

102-76-1 Structure
IdentificationMore
[Name]

Triacetin
[CAS]

102-76-1
[Synonyms]

1,2,3-PROPANETRIOL TRIACETATE
1,2,3-TRIACETOXYPROPANE
1,2,3-TRIACETYLGLYCEROL
FEMA 2007
GLYCERIN TRIACETATE
GLYCEROL TRIACETATE
GLYCERYL TRIACETATE
TRIACETIN
TRIACETIN (C2:0)
Triacetyl glycerin
1,2,3-propanedioltriacetate
1,2,3-propanedioltriethanoate
2-(Acetyloxy)-1-[(acetyloxy)methyl]ethyl acetate
Acetin, tri-
Enzactin
femanumber2007
Fungacetin
Glycerol triacetate tributyrin
Glyped
Kesscoflex TRA
[EINECS(EC#)]

203-051-9
[Molecular Formula]

C9H14O6
[MDL Number]

MFCD00008716
[Molecular Weight]

218.2
[MOL File]

102-76-1.mol
Chemical PropertiesBack Directory
[Appearance]

Colorless liquid; slight fatty odor; bitter taste. Slightly soluble in water; very soluble in alcohol, ether, and other organic solvents. Combustible.
[Melting point ]

3 °C(lit.)
[Boiling point ]

258-260 °C(lit.)
[density ]

1.16 g/mL at 25 °C(lit.)
[vapor density ]

7.52 (vs air)
[vapor pressure ]

0.00248 mm Hg @ 250C
[FEMA ]

2007
[refractive index ]

n25/D 1.429-1.431(lit.)
[Fp ]

300 °F
[storage temp. ]

Sealed in dry,Room Temperature
[solubility ]

Soluble in water, miscible with ethanol (96 per cent) and toluene.
[form ]

Liquid
[color ]

Clear colorless
[Odor]

Characteristic odour
[Stability:]

Stable. Incompatible with strong oxidizing agents. Combustible.
[explosive limit]

1.05%, 189°F
[Odor Type]

fruity
[Water Solubility ]

64.0 g/L (20 ºC)
[JECFA Number]

920
[Merck ]

9589
[BRN ]

1792353
[Dielectric constant]

7.2(20℃)
[Contact allergens]

Triacetin is a component of cigarette filters, which induced a contact dermatitis in a worker at a cigarette manufactory.
[InChIKey]

URAYPUMNDPQOKB-UHFFFAOYSA-N
[LogP]

0.25
[Uses]

Triacetin is a colorless, oily liquid of slight fatty odor and bitter taste. It is soluble with water and is miscible with alcohol and ether. It functions in foods as a humectant and solvent.
[CAS DataBase Reference]

102-76-1(CAS DataBase Reference)
[NIST Chemistry Reference]

1,2,3-Propanetriol, triacetate(102-76-1)
[EPA Substance Registry System]

102-76-1(EPA Substance)
Hazard InformationBack Directory
[Definition]

ChEBI: A triglyceride obtained by acetylation of the three hydroxy groups of glycerol. It has fungistatic properties (based on release of acetic acid) and has been used in the topical treatment of minor dermatophyte infections.
[Description]

§ 184.1901(a) Triacetin (C8H14O6) (102-76-1), also known as 1,2,3-propanetriol triacetate or glyceryl triacetate, is the triester of glycerin and acetic acid. Triacetin can be prepared by heating glycerin with acetic anhydride alone or in the presence of finely divided potassium hydrogen sulfate. It can also be prepared by the reaction of oxygen with a liquid-phase mixture of allyl acetate and acetic acid using a bromide salt as a catalyst.
[Originator]

Enzactin,Ayerst,US,1957
[Occurrence]

Reported found in papaya.
[Preparation]

By direct reaction of glycerol with acetic acid in the presence of Twitchell’s reagent, or in benzene solution of glycerol and boiling acetic acid in the presence of a cationic resin (Zeo-Karb H) pretreated with dilute H2SO4.
[Production Methods]

Triacetin is prepared by the esterification of glycerin with acetic anhydride.
[Manufacturing Process]

200 grams of allyl acetate, 450 grams of glacial acetic acid and 3.71 grams of cobaltous bromide were charged to the reactor and the mixture was heated to 100°C. Pure oxygen was then introduced into the reactor below the surface of the liquid reaction mixture at the rate of 0.5 standard cubic feet per hour. Initially, all of the oxygen was consumed, but after a period of time oxygen introduced into the mixture passed through unchanged. During the course of the reaction, a small quantity of gaseous hydrogen bromide (a total of 1.9 grams) was introduced into the reaction zone, along with the oxygen. The reaction was allowed to continue for 6 hours following which the reaction mixture was distilled. Essentially complete conversion of the allyl acetate took place. A yield of 116 grams of glycerol triacetate was obtained, this being accomplished by distilling the glycerol triacetate overhead from the reaction mixture, at an absolute pressure of approximately 13 mm of mercury.
[Therapeutic Function]

Topical antifungal
[Taste threshold values]

Sweet and creamy with an oily mouthfeel.
[General Description]

Triacetin is a triester of glycerin and acetic acid that occurs naturally in papaya. It is mainly used as a synthetic flavoring agent in ice-creams, nonalcoholic beverages and baked goods.
[Pharmaceutical Applications]

Triacetin is mainly used as a hydrophilic plasticizer in both aqueous and solvent-based polymeric coating of capsules, tablets, beads, and granules; typical concentrations used are 10–35% w/w.
Triacetin is used in cosmetics, perfumery, and foods as a solvent and as a fixative in the formulation of perfumes and flavors.
[Clinical Use]

Glyceryl triacetate (Enzactin, Fungacetin) is a colorless, oilyliquid with a slight odor and a bitter taste. The compound issoluble in water and miscible with alcohol and most organicsolvents.
The activity of triacetin is a result of the acetic acid releasedby hydrolysis of the compound by esterases presentin the skin. Acid release is a self-limiting process becausethe esterases are inhibited below pH 4.
[Safety]

Triacetin is used in oral pharmaceutical formulations and is generally regarded as a relatively nontoxic and nonirritant material at the levels employed as an excipient.
LD50 (dog, IV): 1.5 g/kg
LD50 (mouse, IP): 1.4 g/kg
LD50 (mouse, IV): 1.6 g/kg
LD50 (mouse, oral): 1.1 g/kg
LD50 (mouse, SC): 2.3 g/kg
LD50 (rabbit, IV): 0.75 g/kg
LD50 (rat, IP): 2.1 g/kg
LD50 (rat, oral): 3 g/kg
LD50 (rat, SC): 2.8 g/kg
[in vitro]

Litton Bionetics, Inc. (1976) evaluated the mutagenic potential of Triacetin in a plate test using Salmonella typhimurium strains TA1535, TA1537, and TA1538 with and without metabolic activation. Test concentrations were 0.0013%, 0.00065%, and 0.000325% and the solvent was dimethyl sulfoxide (DMSO). A negative control (solvent) and appropriate positive controls were used and gave expected results. Triacetin was not mutagenic with or without metabolic activation.
Unichema Chemie B.V. (1994) reported that Triacetin was not mutagenic at 50 to 5000 μg/plate in an Ames test using S. typhimurium strains TA1535, TA1537, TA98, and TA100 with and without metabolic activation.
[in vivo]

The mutagenic potential of Triacetin was determined using adult Drosophila melanogaster (Efremova 1962). A dose of 0.2 to 0.3 mg Triacetin had a spontaneous mutation rate of approximately one mutation per 750 chromosomes.
[storage]

Triacetin is stable and should be stored in a well-closed, nonmetallic container, in a cool, dry place.
[Incompatibilities]

Triacetin is incompatible with metals and may react with oxidizing agents. Triacetin may destroy rayon fabric.
[Regulatory Status]

GRAS listed. Accepted in Europe as a food additive in certain applications. Included in the FDA Inactive Ingredients Database (oral capsules and tablets and gels). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Safety DataBack Directory
[Safety Statements ]

S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes .
[WGK Germany ]

1
[RTECS ]

AK3675000
[Autoignition Temperature]

809 °F
[TSCA ]

Yes
[HS Code ]

29153930
[Safety Profile]

Poison by ingestion. Moderately toxic by intraperitoneal, subcutaneous, and intravenous routes. An eye irritant. Combustible when exposed to heat, flame, or powerful oxidizers. To fight fire, use alcohol foam, water, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.
[Hazardous Substances Data]

102-76-1(Hazardous Substances Data)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Ethyl acetate-->Acetic acid-->Glycerol-->Dehydrolyzing agent-->Amyl acetate-->Allyl acetate-->Oxygen
[Preparation Products]

ACETYLATEDMONO-GLYCERIDES-->ETHANOL-1,1-D2-->2-hydroxypropane-1,3-diyl diacetate
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

1,2,3-Triacetoxypropane(102-76-1).msds
Questions And AnswerBack Directory
[Chemical properties]

Colorless, odorless oily liquid. It is miscible with ethanol, ether, benzene, chloroform and other organic solvents, soluble in acetone, insoluble in mineral oil. Slightly soluble in water. 25 ° C in water solubility of 5.9g / 100ml.
Triacetin
[Uses]

  • As a plasticizer and fragrance fixative, ink solvent, also used in medicine and dye synthesis.
  • As a chromatographic fixative, solvent, toughener and fragrance fixative.
  • Humectants; carrier solvents; plasticizers; it can absorb carbon dioxide from the natural gas.
  • In the production of cosmetics, pharmaceuticals and dyes, plasticizers for cigarette filter rods, and so on.
  • Applied in cosmetics, casting, medicine, dyes and other industries. This product is non-toxic, non-irritating.
  • As the substrate for the determination of lipase, perfume fixative, solvent, gas chromatographic fixative (maximum temperature of 85 ℃, solvent: methanol, chloroform), separation of gas and aldehyde analysis.
[Production]

It can be derived from the esterification of glycerol and acetic acid. After preheating glycerol to 50-60 ° C, add acetic acid, benzene and sulfuric acid. Heat and stir for refluxing dehydration, and recycle the benzene. Then add acetic anhydride for heating of 4h. After cooling, the mixture was neutralized with 5% sodium carbonate to pH 7, and the crude layer was dried and the crude oil was dried with calcium chloride. Distill under reduced pressure, collect the 128-131 ° C (0.93 kPa) fraction, namely glycerol triacetate.
[Content analysis]

Accurately weigh about 1g of the sample, put it into a suitable pressure bottle, add 25 mL of 1mol / L. potassium hydroxide solution and 15 mL of isopropyl alcohol, add stopper, wrap with cloth and put it in a canvas bag. Put it into the water bath of 98 ℃ ± 2 ℃ for 1h, and the water level in the water bath should be slightly higher than the bottle level. Take the bottle out from the bag, cool it to room temperature in the air, unfold the cloth and stopper to release the residual pressure in the bottle, and then remove the cloth. Add 6 to 8 drops of phenolphthalein test solution (TS-167), apply 0.5mol / L sulfuric acid for titration of excess alkali until the pink could just disappeared. At the same time, perform a blank test. Each mL of 0.5mol / L sulfuric acid is equivalent to 36.37 mg of glyceryl triacetate (C9H14O6).
[Toxicity]

ADI is not subject to special provisions (FAO / WHO, 2001).
GR.AS (FDA, § 182.1901, 2000).
LD50 3000mg / kg (rat, oral).
Spectrum DetailBack Directory
[Spectrum Detail]

Triacetin(102-76-1)MS
Triacetin(102-76-1)1HNMR
Triacetin(102-76-1)13CNMR
Triacetin(102-76-1)IR1
Triacetin(102-76-1)IR2
Triacetin(102-76-1)Raman
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

Triacetin, 99%(102-76-1)
[Alfa Aesar]

Glycerol triacetate, 99%(102-76-1)
[Sigma Aldrich]

102-76-1(sigmaaldrich)
[TCI AMERICA]

Triacetin,>98.0%(GC)(102-76-1)
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