| Identification | More | [Name]
4-Chlorobenzaldehyde | [CAS]
104-88-1 | [Synonyms]
4-CHLOROBENZALDEHYDE
4-Chlorobenzoic aldehyde
AKOS BBS-00003190
AMMONIA
AMMONIA 10 ION CHROMATOGRAPHY STANDARD
AMMONIA 10K ION CHROMATOGRAPHY STANDARD
AMMONIA 1 ION CHROMATOGRAPHY STANDARD
AMMONIA 1K ION CHROMATOGRAPHY STANDARD
AMMONIA, FREE REAGENT
AMMONIA GAS
AMMONIA MONITOR BUFFER
AMMONIA MONITOR FIRST REAGENT
AMMONIA MONITOR REAGENT
AMMONIA MONITOR REAGENT 1
AMMONIA MONITOR REAGENT 2
AMMONIA MONITOR SECOND REAGENT
AMMONIA MONITOR STANDARD
AMMONIA NO 1
AMMONIA NO 2
AMMONIA SOLUTION, STRONG | [EINECS(EC#)]
203-247-4 | [Molecular Formula]
C7H5ClO | [MDL Number]
MFCD00011418 | [Molecular Weight]
140.57 | [MOL File]
104-88-1.mol |
| Chemical Properties | Back Directory | [Appearance]
colourless to light yellow crystalline powder | [Melting point ]
46 °C | [Boiling point ]
213-214℃ | [density ]
1.196 | [vapor density ]
0.6 (vs air)
| [vapor pressure ]
8.75 atm ( 21 °C)
| [refractive index ]
1.5550 (estimate) | [Fp ]
52 °F
| [storage temp. ]
Store below +30°C. | [solubility ]
935mg/l | [form ]
Liquid | [color ]
White to pale yellow | [Stability:]
Stable, but air and light-sensitive. Incompatible with strong bases, strong reducing agents, strong oxidizing agents. | [Water Solubility ]
935 mg/L (20 ºC) | [Sensitive ]
Air Sensitive | [Detection Methods]
GC,NMR | [BRN ]
385858 | [Dielectric constant]
72（0.0℃） | [InChIKey]
AVPYQKSLYISFPO-UHFFFAOYSA-N | [LogP]
2.34 at 25℃ and pH7 | [CAS DataBase Reference]
104-88-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzaldehyde, 4-chloro-(104-88-1) | [Storage Precautions]
Light sensitive;Store under nitrogen;Air sensitive | [EPA Substance Registry System]
104-88-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
F,C,N,Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin .
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36/38:Irritating to eyes and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 1219 3/PG 2
| [WGK Germany ]
2
| [RTECS ]
CU5076000
| [F ]
8-9 | [Autoignition Temperature]
302 °C | [TSCA ]
Yes | [HazardClass ]
9 | [PackingGroup ]
III | [HS Code ]
29130000 | [Toxicity]
LD50 orally in Rabbit: 840 mg/kg LD50 dermal Rat 5000 mg/kg |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Chlorine-->Manganese dioxide-->2,2'-Azobis(2-methylpropionitrile)-->4-Chlorotoluene-->4-Chlorobenzyl chloride-->Metallic oxides-->BENZAL CHLORIDE | [Preparation Products]
2,4-Dinitroaniline-->α-phenyl-2-p-tolylethylamine-->Propionamide-->Boron nitride-->4-Chloro-3-nitrobenzaldehyde-->Chlorfenapyr-->3-(4-CHLORO-PHENYL)-PROPIONALDEHYDE-->Dodecylamine-->Ammonium L-tartrate-->Robenidine hydrochloride-->Dithizone-->Aceglutamide-->2,5-Dihydro-2,5-dimethoxyfuran-->Felbamate-->HOMOPIPERONYLAMINE-->UNICONAZOLE-->Tetrabutyl titanate-->Acid Blue 83-->1H-Benzotriazol-1-yloxytris(dimethylamino)phosphonium Hexafluorophosphate-->(4-CHLORO-BENZYL)-METHYL-AMINE-->Baclofen-->Synthetic greasing agent-->4-CHLORO-ALPHA-(METHYLAMINO)BENZENE ACETIC ACID-->2-Amino-2-phenylacetic acid-->NEOCUPFERRON-->AMMONIUM O,O-DIISOPROPYLTHIOPHOSPHATE-->Cyromazine-->4-Chlorobenzyl pinacolone-->Anilinoacetic acid-->Chlormezanone-->1,3-diisopropyl-2-isothiocyanato-5-phenoxybenzene-->4-Chlorocinnamic acid-->1-amino-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylicaci-->Uniconazole-->5-chloro-alpha,alpha-bis(3,5-dichloro-2-hydroxyphenyl)-2-toluenesulfonic-->2-(4-CHLOROPHENYL)-3-METHYL-TETRAHYDRO-1,3-THIAZINE-4-ONE-->N-[(4-CHLOROPHENYL)METHYLENE]METHANAMINE-->Oxcarbazepine-->3-ETHYLSULFONYL-2-PYRIDINESULFONAMIDE |
| Hazard Information | Back Directory | [General Description]
Colorless to yellow powder or white crystalline solid. Pungent odor. | [Reactivity Profile]
4-CHLOROBENZALDEHYDE(104-88-1) is sensitive to exposure to air. 4-CHLOROBENZALDEHYDE(104-88-1) is also sensitive to light. REACTIVITY: This chemical is incompatible with strong bases, strong oxidizers and strong reducing agents. | [Air & Water Reactions]
This chemical is sensitive to exposure to air. Insoluble in water. | [Fire Hazard]
This chemical is combustible. | [Chemical Properties]
4-chlorobenzaldehyde appears as colourless to light yellow crystalline powder. Insoluble in water, easily soluble in ethanol, ether, benzene, soluble in water, acetone. Can be volatilized with water vapor. It can produced by the oxidation of 4-chlorobenzyl alcohol. 4-chlorobenzaldehyde is the intermediate of fungicide tebuconazole and plant growth regulator uniconazole. | [Uses]
4-Chlorobenzaldehyde is used as an intermediate for the manufacture of dyestuffs, optical brighteners, pharmaceuticals, agricultural chemicals and metal finishing products. | [Preparation]
4-Chlorobenzaldehyde can be obtained by chlorinated hydrolysis of p-chlorotoluene: add p-chlorotoluene and phosphorus trichloride to the reaction pot, raise the temperature to 155°C under light and pass chlorine. Control the temperature at 160-170℃ and pass chlorine to the calculated amount to obtain the chlorination solution. Add it to concentrated sulfuric acid with stirring, and stir for 5h at room temperature. let it stand and stratify, take the lower layer into ice water to crystallize, and filter it when it is cold to below 5℃. The filter cake was washed with ice water to obtain the crude product, distilled under reduced pressure and collected 108-111℃ (3.33kPa) fraction to obtain p-chlorobenzaldehyde. | [Synthesis Reference(s)]
Synthetic Communications, 26, p. 1, 1996 DOI: 10.1080/00397919608003856
Tetrahedron Letters, 43, p. 1395, 2002 DOI: 10.1016/S0040-4039(02)00027-8 | [Purification Methods]
Crystallise it from EtOH/water (3:1), then sublime it twice at ~50o/2mm. [Beilstein 7 H 235, 7 IV 568.] |
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