ChemicalBook--->CAS DataBase List--->35943-35-2

35943-35-2

35943-35-2 Structure

35943-35-2 Structure
IdentificationBack Directory
[Name]

API-2
[CAS]

35943-35-2
[Synonyms]

TCN
IAP1
MIHC
MYHL
BBMI
MYO1A
RNF49
BIRC3
API-2
nosyl-
DFNA48
3-amine
VD-0002
hthylene
uranosyl-
Myosin-Ia
Anti-Myhl
NSC 154020
Inhibitor V
TRICIRIBINE
Anti-Dfna48
Anti-Myosin ia
AKT INHIBITOR V
API-2 (Tricirbine)
Triciribine hydrate
TRICYCLIC NUCLEOSIDE
pentaazacentopthylene
Brush border myosin I
AKT/PKB SIGNALING INHIBITOR-2
Anti-MYO1A antibody produced in rabbit
ANTI-MYO1A (CENTER S291) antibody produced in rabbit
ANTI-CIAP2 (BIRC3)(N-TERMINAL) antibody produced in rabbit
4,5,6,8-pentaazaacenaphthylen-5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1
1,4,5,6,8-pentaazaacenaphthylene,3-amino-1,5-dihydro-5-methyl-1-beta-d-ribof
3-amino-1,5-dihydro-5-methyl-1-beta-d-ribofuranosyl-1,4,5,6,8-pentaazaacenap
1,4,5,6,8-pentaazaacenaphthylen-3-amine,1,5-dihydro-5-methyl-1-beta-d-ribofura
1,5-Dihydro-5-methyl-1-β-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
(1,4,5,6,8-Pentaazaacenaphthylen-3-aMine,1,5-dihydro-5-Methyl-1-b-D-ribofuranosyl-)
1,5-DIHYDRO-5-METHYL-1-BETA-D-RIBOFURANOSYL-1,4,5,6,8-PENTAAZAACENAPHTHYLEN-3-AMINE
6-AMino-4-Methyl-8-(β-D-ribofuranosyl)-4H,8H-pyrrolo[4,3,2-de]pyriMido[4,5-c]pyridazine
6-AMINO-4-METHYL-8-(BETA-D-RIBOFURANOSYL)-4H,8H-PYRROLO[4,3,2-DE]PYRIMIDO[4,5-C]PYRIDAZINE
Triciribine 1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine
1,5-Dihydro-5-methyl-1-beta-D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine Triciribine
(2R,3R,4S,5R)-2-(3-aMino-5-Methyl-1,4,5,6,8-pentaazaacenaphthylen-1(5H)-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol
[Molecular Formula]

C13H16N6O4
[MDL Number]

MFCD00932413
[MOL File]

35943-35-2.mol
[Molecular Weight]

320.3
Chemical PropertiesBack Directory
[Melting point ]

207 °C (decomp)
[Boiling point ]

459.21°C (rough estimate)
[density ]

1.2633 (rough estimate)
[refractive index ]

1.7000 (estimate)
[storage temp. ]

Store at RT
[solubility ]

DMSO: >10mg/mL
[form ]

powder
[pka]

12.35±0.70(Predicted)
[color ]

tan
[InChIKey]

HOGVTUZUJGHKPL-HTVVRFAVSA-N
Hazard InformationBack Directory
[Chemical Properties]

Off-White Solid
[Usage]

Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is al so a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.
[Biological Activity]

Selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3 β and AFX. In vitro, induces apoptosis and growth arrest preferentially in human cancer cells with elevated levels of Akt. In mice, potently and selectively inhibits growth of Akt-overexpressing tumors. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and-2.
[Uses]

Triciribine is an antitumor tricyclic nucleoside. Triciribine acts as a potent, small-molecule inhibitor of AKT phosphorylation in subjects with solid tumors contining activated AKT. Triciribine is al so a selective inhibitor of HIV-1 and HIV-2, including strains known to be resistant to AZT or TIBO.
[Definition]

ChEBI: Triciribine is a nucleoside analogue in which the nucleobase portion is a 1,4,5,6,8-pentaazaacenaphthylene ring system substituted with an amino group at position 3, and a methyl group at position 5 and is bound to the beta-D-ribofuranosyl moiety by an N(1)-glycosidic linkage. It has a role as an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor.
[Biochem/physiol Actions]

Triciribine is a highly selective Akt/PKB inhibitor, that selectively inhibits the cellular phosphorylation/activation of Akt1/2/3.
[storage]

Store at -20°C
Safety DataBack Directory
[WGK Germany ]

3
[RTECS ]

RY8455000
Spectrum DetailBack Directory
[Spectrum Detail]

API-2(35943-35-2)1HNMR
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