| Identification | More | [Name]
CT SUPPLEMENT | [CAS]
359875-09-5 | [Synonyms]
FEMA 2306
CT SUPPLEMENT
CJ 11972 hydrate
Maropitant citrate
TIMTEC-BB SBB008922
Maropitant citrate [USAN]
Maropitant citrate hydrate
ACIDUM CITRICUM ANHYDRICUM
HYDROXYTRICARBALLYLIC ACID
B-HYDROXYTRICARBALLYLIC ACID
TELLURITE CEFIXIM SUPPLEMENT
CEFIXIM TELLURITE SUPPLEMENT
Maropitant Citrate USP/EP/BP
CITRATE ION CHROMATOGRAPHY STANDARD
2-HYDROXYPROPANE-1,2,3-TRICARBOXYLIC ACID
ethyl[(1R)-1-[(2R)-oxolan-2-yl]-2-phenylethyl]amine
Cefixim Tellurite Supplement, Tellurite Cefixim Supplement
4-(4-fluorophenyl)-1-[4-(1,2,4-triazol-1-yl)butyl]-3,6-dihydro-2H-pyridine
(7S,8S)-7-benzhydryl-N-[(2-methoxy-5-tert-butyl-phenyl)methyl]-1-azabicyclo[2.2.2]octan-8-amine
(2S,3S)-2-benzhydryl-N-[(5-tert-butyl-2-methoxyphenyl)methyl]-1-azabicyclo[2.2.2]octan-3-amine,2-hydroxypropane-1,2,3-tricarboxylic acid,hydrate
Maropitant Citrate,CJ-11,972,ACIDUM CITRICUM ANHYDRICUM,B-HYDROXYTRICARBALLYLIC ACID,HYDROXYTRICARBALLYLIC ACID,FEMA 2306,CEFIXIM TELLURITE SUPPLEMENT,CITRATE ION CHROMATOGRAPHY STANDARD,CT SUP | [EINECS(EC#)]
201-069-1 | [Molecular Formula]
C23H29FN4O7 | [MDL Number]
MFCD02098080 | [Molecular Weight]
660.81 | [MOL File]
359875-09-5.mol |
| Chemical Properties | Back Directory | [Melting point ]
153-159 °C(lit.)
| [Fp ]
100 °C
| [storage temp. ]
2-8°C | [solubility ]
H2O: 1 M at 20 °C, clear, colorless
| [form ]
grit
| [Water Solubility ]
Water: 3 mg/mL (4.42 mM) | [InChIKey]
XDZPFSKCXRGRIO-OHTRWSNQNA-N | [SMILES]
C(O)(C(=O)O)(CC(=O)O)CC(=O)O.C(C1C=CC=CC=1)(C1C=CC=CC=1)[C@@H]1N2CCC(CC2)[C@@H]1NCC1C=C(C(C)(C)C)C=CC=1OC |&1:26,33,r| | [CAS DataBase Reference]
359875-09-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,T | [Risk Statements ]
R41:Risk of serious damage to eyes.
R42/43:May cause sensitization by inhalation and skin contact .
R36/37/38:Irritating to eyes, respiratory system and skin .
R25:Toxic if swallowed. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves .
S22:Do not breathe dust . | [RIDADR ]
UN 3284 6.1/PG 3 | [WGK Germany ]
1 | [RTECS ]
GE7350000 | [F ]
9 |
| Hazard Information | Back Directory | [Description]
Maropitant citrate hydrate is a specific neurokinin-1 (NK-1) receptor antagonist that selectively inhibits the production of substance P, a mediator involved in signalling vomiting. Maropitant citrate was therefore originally used to treat vomiting in dogs and cats. Currently, it is also used as an adjunct to visceral analgesia in dogs and cats, and in other species such as horses and birds. | [Uses]
Anti-emetic. | [Pharmacokinetics]
The maximum, minimum, and average concentrations of maropitant achieved at steady state were 375.5 ± 200, 16.8 ± 7.7, and 73.5 ± 45.1 ng/ml, respectively. The terminal elimination half-life was 11.6 ± 1.4 hr, and the accumulation index was 1.3 ± 0.07. Heart rate decreased between Day 1 and Day 5 (p = .005), with three horses having heart rates of 20 beats per minute and atrioventricular block on Day 5. Pharmacokinetics of repeated maropitant administration suggests the drug could be considered for use in healthy horses. | [Veterinary Drugs and Treatments]
Maropitant citrate injectable solution is indicated for the prevention
and treatment of acute vomiting in dogs; maropitant citrate
tablets are indicated for the prevention of acute vomiting and the
prevention of vomiting due to motion sickness in dogs. Both are
also used extra-label in cats. |
|
|