| Identification | More | [Name]
Cycloleucine | [CAS]
52-52-8 | [Synonyms]
1-AMINO-1-CARBOXYCYCLOPENTANE
1-AMINO-1-CYCLOPENTANECARBOXYLIC ACID
1-AMINOCYCLOPENTANE-1-CARBOXYLIC ACID
1-AMINOCYCLOPENTANECARBOXYLIC ACID
ACPC
CYCLEU
CYCLOLEUCINE
H-AC5C-OH
H-CLE-OH
H-NH(1)CPEN-OH
RARECHEM AK HD C019
TIMTEC-BB SBB004230
1-amino-cyclopentanecarboxylicaci
Amino-1-cyclopentanecarboxylic acid
CB 1639
cb1639
Cycloleucin
Cyclopentanecarboxylic Acid, 1-amino-, L-
Cyclopentanecarboxylic acid, L-amino
l-cyclopentanecarboxylicaci | [EINECS(EC#)]
200-144-6 | [Molecular Formula]
C6H11NO2 | [MDL Number]
MFCD00001381 | [Molecular Weight]
129.16 | [MOL File]
52-52-8.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
GY2625000
| [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29224999 | [Hazardous Substances Data]
52-52-8(Hazardous Substances Data) | [Toxicity]
LD50 oral in rat: 290mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
WHITE TO BEIGE CRYSTALLINE FLAKES OR POWDER | [Uses]
Cycloleucine is a synthetic amino acid used in numerous biochemical transport studies
| [Uses]
NMDA receptor antagonist, inhibits nucleic acid methylation; adrenergic agonist | [Definition]
ChEBI: A non-proteinogenic alpha-amino acid that is cyclopentane substituted at position 1 by amino and carboxy groups. | [General Description]
Cycloleucine is a nonmetabolizable amino acid widely used as a building block in peptide synthesis. | [Purification Methods]
Any Cl -or other anions are removed by stirring with a strong cation exchange resin (Amberlite IR-120), filtering, and washing with distilled H2O until the filtrate is free from the anion. The resin is then stirred overnight with 6N NH4OH, filtered, the filtrate is decolourised (charcoal) and evaporated to dryness in a vacuum. The residue is recrystallised from H2O/EtOH. Also crystallise it from aqueous EtOH. The hydrochloride has m 222-224o(dec). [Neelakantan & Hartung J Org Chem 23 967 1958, Connors & Ross J Chem Soc 2119 1960. O’Donnell et al. Synthesis 127 1984, Beilstein 14 IV 974.] |
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