| Identification | More | [Name]
3-Nitrophenol | [CAS]
554-84-7 | [Synonyms]
3-Hydroxy-1-nitrobenzene
3-NITROPHENOL
M-NITROPHENOL
M-NITROPHENOL INDICATOR
1-Hydroxy-3-nitrobenzene
3-Hydroxynitrobenzene
3-Hydroxy-nitrobenzene
3-hydroxynitrobenzene[qr]
3-nitro-pheno
crumpleather-lastingdressing[qr]
meta-Nitrophenol
m-Hydroxynitrobenzene
m-hydroxynitrobenzene[qr]
m-Nitrofenol
m-nitro-pheno
m-nitrophenol(3-nitrophenol)
m-nitrophenol[qr]
Phenol, m-nitro-
Phenol,3-nitro-
phenol,3-nitro-[qr] | [EINECS(EC#)]
209-073-5 | [Molecular Formula]
C6H5NO3 | [MDL Number]
MFCD00007240 | [Molecular Weight]
139.11 | [MOL File]
554-84-7.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow to brown crystalline powder | [Melting point ]
96-98 °C (lit.) | [Boiling point ]
194 °C/70 mmHg (lit.) | [density ]
1,49 g/cm3 | [refractive index ]
1.5723 (estimate) | [Fp ]
102°C | [storage temp. ]
Store at +5°C to +30°C. | [solubility ]
13.5g/l insoluble | [form ]
Crystalline Powder | [pka]
8.28(at 25℃) | [color ]
Yellow to brown | [PH]
6.6-8.6 (H2O, 20℃) | [PH Range]
6.6(colourless)-8.6(yellow/orange) | [Water Solubility ]
13.5 g/L (25 ºC) | [λmax]
570nm | [Detection Methods]
HPLC | [Merck ]
14,6619 | [BRN ]
1907946 | [Major Application]
Display device, semiconductor device, sensors, high voltage capacitors, energetic materials, electrolyte batteries, inks, correction fluid, detergent, leak detection method, lubricants, insecticide, food storage, inhibition of amyloidoses, detect bacterialinfection, drugs, material for evaluating dental caries activity | [InChIKey]
RTZZCYNQPHTPPL-UHFFFAOYSA-N | [CAS DataBase Reference]
554-84-7(CAS DataBase Reference) | [NIST Chemistry Reference]
Phenol, 3-nitro-(554-84-7) | [EPA Substance Registry System]
554-84-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R38:Irritating to the skin.
R41:Risk of serious damage to eyes.
R36/37/38:Irritating to eyes, respiratory system and skin .
R33:Danger of cumulative effects.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S22:Do not breathe dust .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) . | [RIDADR ]
UN 1663 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
SM1925000
| [F ]
8 | [Autoignition Temperature]
400 °C | [Hazard Note ]
Harmful/Irritant | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29089000 | [Safety Profile]
Poison by ingestion,
subcutaneous, and intraperitoneal routes.
Moderately toxic by skin contact. A skin and
severe eye irritant. When heated to
decomposition it emits toxic fumes of NOx.
See also other nitrophenol entries. | [Hazardous Substances Data]
554-84-7(Hazardous Substances Data) | [Toxicity]
LD50 orally in mice, rats: 1414, 933 mg/kg, K. C. Back et al., Reclassification of Materials Listed as Transportation Health Hazards (TSA-20-72-3; PB214-270, 1972) |
| Hazard Information | Back Directory | [General Description]
Colorless to pale yellow crystalline solid. Sinks in and mixes with water. | [Reactivity Profile]
M-NITROPHENOL(554-84-7) is a light-yellow, crystalline material, toxic and irritant. When heated to decomposition M-NITROPHENOL(554-84-7) emits toxic fumes of oxides of nitrogen [Lewis, 3rd ed., 1993, p. 941]. Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. | [Air & Water Reactions]
Water insoluble. | [Hazard]
Toxic by ingestion. | [Health Hazard]
INHALATION: Inhalation or ingestion causes headaches, drowsiness, nausea, and blue color in lips, ears, and finger nails (cyanosis). EYES: Contact with eyes causes irritation. SKIN: Can be absorbed through intact skin to give same symptoms as for inhalation. | [Fire Hazard]
Special Hazards of Combustion Products: Dangerous toxic fumes of NO x | [Chemical Properties]
yellow to brown crystalline powder | [Uses]
3-Nitrophenol is a chemical reagent used in various organic syntheses. Used in the synthesis of RAGE inhibitors via the etherification of phenols. Also used in the synthesis of kinase inhibitors again
st epidermal growth factor receptor T790M mutation. | [Uses]
3-Nitrophenol is a chemical reagent used in various organic syntheses. Used in the synthesis of RAGE inhibitors via the etherification of phenols. Also used in the synthesis of kinase inhibitors against epidermal growth factor receptor T790M mutation. | [Uses]
As indicator in 0.3% solution in 50% alcohol. pH: 6.8 colorless, 8.6 yellow. | [Definition]
ChEBI: A member of the class of 3-nitrophenols that is phenol in which one of the hydrogens that is meta to the hydroxy group has been replaced by a nitro group. | [Production Methods]
3-Nitroaniline is diazotized in aqueous sulfuric acid and then hydrolyzed by being added gradually to boiling dilute sulfuric acid. The crude product solidifies on cooling and is filtered off in 90 % yield. | [Synthesis Reference(s)]
Tetrahedron Letters, 36, p. 5117, 1995 DOI: 10.1016/0040-4039(95)00963-D | [Purification Methods]
Crystallise 3-nitrophenol from water, CHCl3, CS2, EtOH or pet ether (b 80-100o), and dry it under vacuum over P2O5 at room temperature. It can also be distilled at low pressure. The 4-nitrobenzoate had m 174o (from EtOH). [Beilstein 6 IV 1269.] |
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