| Identification | More | [Name]
Celiprolol | [CAS]
56980-93-9 | [Synonyms]
3-[3-acetyl-4-(2-hydroxy-3-tert-butylamino-propoxy)-phenyl]-1,1-diethyl-urea
CELIPROLOL
celiptolol
-diethyl-
n’-(3-acetyl-4-(3-((1,1-dimethylethyl)amino)-2-hydroxypropoxy)phenyl)-n,n-di
Celiprolol Base
CELIPROLOLHYDROCHLORIDE(SUBJECTTOPANTENTFREE)
(R,S)-Celiprolol
dl-Celiprolol
Racemic Celiprolol
Selectol
Urea, N'-[3-acetyl-4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-N,N-diethyl-
rac-1,1-Diethyl-3-[3-acetyl-4-[(R*)-2-hydroxy-3-[(1,1-dimethylethyl)amino]propoxy]phenyl]urea
rac-3-[3-Acetyl-4-[(R*)-3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea | [EINECS(EC#)]
260-497-7 | [Molecular Formula]
C20H33N3O4 | [MDL Number]
MFCD00864577 | [Molecular Weight]
379.49 | [MOL File]
56980-93-9.mol |
| Hazard Information | Back Directory | [Originator]
Selectol,Chemie Linz,Austria,1983 | [Uses]
Celiprolol is an intermediate in the synthesis of Celiprolol Hydrochloride (C254500). Celiprolol is a cardioselective β1-adrenergic blocker. Antihypertensive, antianginal. | [Definition]
ChEBI: 3-[3-acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea is an aromatic ketone. | [Manufacturing Process]
3-Acetyl-4-hydroxyaniline, in solution in pyridine, is reacted with
dimethylcarbamoyl chloride at room temperature to give N-(3-acetyl-4-
hydroxy)phenyl-N'-dimethylurea, which after evaporating the pyridine, taking
up the residue in chloroform and evaporating the latter, is obtained in a
crystalline form. Melting point: 160°-162°C. After reaction of the product in
alkaline aqueous solution, with epichlorohydrin, N-[3-acetyl-4-(2',3'-epoxy)-
propoxy]-phenyl-N'-dimethylurea (melting point: 98°-102°C) is obtained, and
this, in turn, is reacted with excess tert-butylamine in aqueous solution at
room temperature to give N-[3-acetyl-4-(3'-tert-butylamino-2'-hydroxy)-
propoxy)-phenyl-N'-dimethylurea of melting point: 120°-122°C. | [Therapeutic Function]
Beta-adrenergic blocker |
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