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60-35-5

60-35-5 Structure

60-35-5 Structure
IdentificationMore
[Name]

Acetamide
[CAS]

60-35-5
[Synonyms]

ACETAMIDE
ACETIC ACID AMIDE
AMIDE C2
ETHANAMIDE
LABOTEST-BB LT00795814
Acetamid
Acetamid(trigonaleForm)
acetamide(ethanamide)
aceticacidamide[qr]
acetimidicacid
acetimidicacid[qr]
Acetylamide
acetylamine
Amid kyseliny octove
amidkyselinyoctove
CH3CONH2
Essigsαureamid
ethanamide[qr]
Methanecarboxamide
methanecarboxamide[qr]
[EINECS(EC#)]

200-473-5
[Molecular Formula]

C2H5NO
[MDL Number]

MFCD00008023
[Molecular Weight]

59.07
[MOL File]

60-35-5.mol
Chemical PropertiesBack Directory
[Appearance]

Acetamide is a colorless to yellow, deliquescent, crystalline solid. Odorless if pure, “mousy” odor if impure. Odor threshold5140 160 milligram per cubic meter.
[Melting point ]

78-80 °C(lit.)
[Boiling point ]

221 °C(lit.)
[density ]

1.159
[vapor pressure ]

1 mm Hg ( 65 °C)
[FEMA ]

4251
[refractive index ]

1.4274
[Fp ]

220-222°C
[storage temp. ]

Store at RT
[solubility ]

H2O: 0.5 g/mL, Hazen ≤50
[form ]

Crystals
[pka]

0.63(at 25℃)
[color ]

White
[Odor]

Mousy odor
[Stability:]

Stable. Incompatible with strong acids, strong oxidizing agents, strong bases. Deliquescent. Triboluminescent.
[Water Solubility ]

2000 g/L (20 ºC)
[JECFA Number]

1592
[Merck ]

14,43
[BRN ]

1071207
[Dielectric constant]

41.0(20℃)
[Exposure limits]

ACGIH: TWA 1 ppm
[InChIKey]

DLFVBJFMPXGRIB-UHFFFAOYSA-N
[LogP]

-1.26
[CAS DataBase Reference]

60-35-5(CAS DataBase Reference)
[IARC]

2B (Vol. 7, Sup 7, 71) 1999
[NIST Chemistry Reference]

Acetamide(60-35-5)
[EPA Substance Registry System]

60-35-5(EPA Substance)
Hazard InformationBack Directory
[Chemical Properties]

Acetamide occurs as hexagonal, colorless deliquescent crystals with a musty odor. It is incompatible with strong acids, strong oxidizing agents, strong bases, and tribolumi- nescent. Acetamide is used primarily as a solvent, as a plasticizer, and a wetting and penetrating agent. Workplace exposures to acetamide are associated with the plastics and chemical industries.
[General Description]

Colorless crystals with a mousy odor (NTP, 1999). Low toxicity.
[Reactivity Profile]

ACETAMIDE(60-35-5) may react with azo and diazo compounds to generate toxic gases. May form flammable gases with strong reducing agents. Reacts as a weak bases (weaker than water). Mixing with dehydrating agents such as P2O5 or SOCl2 generates acetonitrile Burns to give toxic mixed oxides of nitrogen (NOx).
[Air & Water Reactions]

Deliquescent. Very soluble in water.
[Health Hazard]

After oral exposures to acetamide, animals developed liver tumors. However, no informa- tion is available on the carcinogenic effects of acetamide in humans. The US EPA has not classifi ed acetamide for carcinogenicity. The IARC has classifi ed acetamide as a Group 2B, meaning a possible human carcinogen.
[Potential Exposure]

Used as a stabilizer, plasticizer, wetting agent; solvent in plastics, lacquers, explosive; soldering flux ingredient; and chemical manufacturing
[Fire Hazard]

The flash point of this chemical has not been determined, but ACETAMIDE is probably combustible.
[First aid]

If this chemical gets into the eyes, remove any contact lenses at once, and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. If this chemical has been inhaled, remove from exposure and transfer promptly to a medical facility.
[Shipping]

UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required
[Incompatibilities]

Reacts with strong acids, such as hydrochloric, sulfuric, and nitric, strong oxidizers; strong bases; strong reducing agents such as hydrides; ammoniaisocyanates, phenols, cresols. Contact with water causes slow hydrolyzation to ammonia and acetate salts.
[Waste Disposal]

Add to alcohol or benzene as a flammable solvent and incinerate; oxides of nitrogen produced may be scrubbed out with alkaline solution. All federal, state, and local environmental regulations must be observed.
[Uses]

  1. Acetamide is often used as plasticizer and as industrial solvent.
  2. molten acetamide is an excellent solvent for many organic and inorganic compounds.
  3. Solubilizer.
  4. renders sparingly soluble substances more soluble in water by mere addition or by fusion.
  5. stabilizer.
  6. manufacture of methylamine, denaturing alcohol.
  7. In organic syntheses.
  8. Acetamide is used as a co-monomer in the production of polymeric materials such as polyvinyl acetamide, a polymeric product used as an absorbent.
  9. It can be used for the transamidation of carbxamides in 1,4-dioxane in the absence of a catalyst.
[Uses]

As a dipolar solvent, acetamide finds many uses as a solvent for both inorganic and organic compounds. The solvency has led to widespread uses in industry including applications in cryoscopy, soldering, and the textile industry. The neutral and amphoteric characteristics allow its use as an antacid in the lacquer, explosives, and cosmetics industries. Its hygroscopic properties make it useful as a plasticizer in coatings, fixtures, cloth, and leather, and as a humectant for paper. It is also a raw material in organic synthesis of methylamine and thioacetamide and as an intermediate in preparation of medicines, insecticides, and plastics.
[Uses]

Cryoscopy; organic synthesis; general solvent; lacquers; explosives, soldering flux; wetting agent; plasticizer
[Definition]

ChEBI: Acetamide is a member of the class of acetamides that results from the formal condensation of acetic acid with ammonia. It is a monocarboxylic acid amide, a N-acylammonia and a member of acetamides. It is a tautomer of an acetimidic acid.
[target]

Histone Methyltransferase
[Carcinogenicity]

The IARC has determined that there is sufficient evidence of carcinogenicity for acetamide in experimental animals and that it is possibly carcinogenic to humans.
[Environmental Fate]

The mechanism of toxicity of acetamide is not known; the response profile is quite different from the better studied dimethyl derivative. Acetamide appears to be in a class of chemicals which, although producing liver cancer in rodents, is less sensitive to inactive in genetic tests looking at formation of micronuclei. The carcinogenic response in rodents appears related to the formation of hydroxylamine from the primary metabolite acetohydroxamic acid.
[Purification Methods]

Acetamide is crystallised by dissolving in hot MeOH (0.8mL/g), diluting with Et2O and allowing to stand [Wagner J Chem Edu 7 1135 1930]. Alternate crystallisation solvents are acetone, *benzene, chloroform, dioxane, methyl acetate or *benzene/ethyl acetate mixtures (3:1 and 1:1). It has also been recrystallised from hot water after treating with HCl-washed activated charcoal (which had been repeatedly washed with water until free from chloride ions), then crystallised again from hot 50% aqueous EtOH and finally twice from hot 95% EtOH [Christoffers & Kegeles J Am Chem Soc 85 2562 1963]. Finally it is dried in a vacuum desiccator over P2O5. Acetamide is also purified by distillation (b 221-223o) or by sublimation in vacuo. It has also been purified by two recrystallisations from cyclohexane containing 5% (v/v) of *benzene. Needle-like crystals separate and are filtered, washed with a small volume of distilled H2O and dried with a flow of dry N2. [Slebocka-Tilk et al. J Am Chem Soc 109 4620 1987, Beilstein 2 H 175, 2 I 80, 2 II 177, 2 III 384, 2 IV 399.]
[Toxicity evaluation]

Acetamide will exist as a vapor in the ambient atmosphere. Atmospheric degradation occurs by reaction with photochemically produced hydroxyl radicals. The half-life for this reaction in air is estimated to be 7.6 days. If released to soil, acetamide is expected to have very high mobility and is not expected to adsorb to suspended solids and sediment. Experiments suggest that this chemical may break down in the environment through biodegradation and not through hydrolysis. Volatilization from water surfaces is not expected to be an important fate process based on this compound’s estimated Henry’s law constant.
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

R40:Limited evidence of a carcinogenic effect.
[Safety Statements ]

S36/37:Wear suitable protective clothing and gloves .
[RIDADR ]

UN 3077 9/PG 3
[WGK Germany ]

1
[RTECS ]

AB4025000
[F ]

3
[Autoignition Temperature]

560°C
[TSCA ]

Yes
[HS Code ]

29241900
[storage]

Acetamide should be kept stored in a tightly closed container, in a cool, dry, ventilated area. It should be protected against physical damage, away from any source of heat, ignition, or oxidizing materials.
[Precautions]

During handling and/use of acetamide, workers should wear special protective equipment. After leaving work areas, workers should wash hands, face, forearms, and neck, dispose of outer clothing, and change to clean garments at the end of the day.
[Safety Profile]

Suspected carcinogen with experimental carcinogenic and neoplastigenic data. Moderately toxic by intraperitoneal and possibly other routes. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. See also AMIDES. When heated to decomposition it emits toxic fumes of NOx,.
[Hazardous Substances Data]

60-35-5(Hazardous Substances Data)
[Toxicity]

LD50 orally in Rabbit: 7000 mg/kg
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Ammonia-->1,4-Dioxane-->Ammonium acetate-->Ammonium carbonate-->Ethyl phenylacetate-->Phenylacetone
[Preparation Products]

Chorionic Gonadotropin-->3-AMINO-PYRIDINE-4-CARBALDEHYDE-->Triethyl orthoacetate-->Thidiazuron-->Cefaclor monohydrate-->3-AMINO-ISONICOTINIC ACID ETHYL ESTER-->3-Amino-2-pyridinecarboxylic acid-->2-FLUOROQUINOLINE-7-CARBOXYLIC ACID-->(3-AMINO-PYRIDIN-4-YL)-METHANOL-->4-HYDROXYMETHYL-PYRIDIN-3-OL-->3-AMINO-ISONICOTINIC ACID METHYL ESTER-->N-Acetylsulfanilyl chloride-->4-ETHYL-6-HYDROXY-2-METHYLPYRIMIDINE-->3-HYDROXY-4-PYRIDINECARBOXYLIC ACID-->Thioacetamide-->3-Aminoisonicotinic acid-->1,2,4,5-TETRACYANOBENZENE-->Glycinamide-->3-TERT-BUTOXYCARBONYLAMINO-ISONICOTINIC ACID-->1,2,4,5-BENZENETETRACARBOXAMIDE-->Ethyl fluoroacetate-->3-IODOISONICOTINIC ACID-->2,4-Dimethylthiazole-->3-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ISONICOTINIC ACID-->3-(2,2-DIMETHYL-PROPIONYLAMINO)-ISONICOTINIC ACID-->3-AMINO-4-PYRIDINECARBOXYALDEHYDE HYDROCHLORIDE-->4-CHLORO-2,6-DIMETHYL-NICOTINIC ACID-->ETHYL 4-CHLORO-2,6-DIMETHYLPYRIDINE-3-CARBOXYLATE-->PYROMELLITIC DIIMIDE-->Dacarbazine-->Cymoxanil-->4-Amino-6-chloropyrimidine-->HEXANENITRILE-->N,O-Bis(trimethylsilyl)acetamide-->N-ACETYLHOMOPIPERAZINE-->3,4-PYRIDINEDICARBOXIMIDE-->BENORILATE-->4-Amino-5-imidazolecarboxamide hydrochloride-->Trimethyl thiazole-->2-Methylthiazole
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Ethanamide(60-35-5).msds
Questions and Answers (Q&A)Back Directory
[Description]

Acetamide (MEA or ethanamide),  the amide of acetic acid, is a white crystalline solid in pure form with a mousy odor. Low toxicity. It is produced by dehydrating ammonium acetate. Acetamide is found in red beetroot.
Acetamide is used primarily as a solvent, plasticizer, and a wetting and penetrating agent. it was used as an intermediate in the synthesis of methylamine, thioacetamide, hypnotics, insecticides, medicinals and various plastics, a soldering flux ingredient, a wetting agent and penetration accelerator for dyes, and as a plasticizer in leather, cloth and coatings.
ethanolamine is an amide made from acetamide and monoethanolamine. It is a clear liquid. In cosmetics and personal care products, It is used in the formulation of bubble baths, hair conditioners, shampoos, wave sets, moisturizers, and other bath and hair care products.It increases the water content of the top layers of the skin by drawing moisture from the surrounding air. It also enhances the appearance and feel of hair, by increasing hair body, suppleness, or sheen, or by improving the texture of hair that has been damaged physically or by chemical treatment.
Questions And AnswerBack Directory
[Synthesis]

Laboratory synthesis can be carried out according to the following steps. Put 3kg glacial acetic acid into a 5L flask and add ammonium carbonate equivalent to 400g ammonia. The flask is equipped with a high-efficiency fractionation column, a condenser and a receiver. Heat the reaction mixture until it boils slowly, adjust the heating so that the distillation rate does not exceed 180mg / h until the top temperature reaches 110 ℃. A mixture of 1400-1500 ml of water and acetic acid was obtained. Change the receiver, slowly increase the heating, and continue the distillation at the same speed until the top temperature rises to 140 ℃. The distillate is 500-700ml, mainly acetic acid, which is reserved for the next feeding. Transfer the residue into a flask with fractionation column and air condenser, distill under normal pressure, and collect the fractions before 210 ℃ and 210-216 ℃ respectively. The latter is acetamide, weighing 1150-1200g. The former can also distill and recover some products. The total weight of the two is 1200-1250g, and the yield is 87% - 90%.
The recrystallization of acetylamine is usually carried out by distillation and solvent recrystallization. The commonly used solvents are acetone, benzene, ethyl acetate, methyl acetate, chloroform, dioxane or the mixture of benzene and ethyl acetate. For example, 1kg of acetamide prepared by the above method is recrystallized with a mixed solvent of 1l benzene and 300ml ethyl acetate to obtain a colorless needle like pure product. The purity of products obtained from industrial production shall not be lower than 98%, and the freezing point shall not be lower than 76 ℃.
Spectrum DetailBack Directory
[Spectrum Detail]

Acetamide(60-35-5)MS
Acetamide(60-35-5)1HNMR
Acetamide(60-35-5)13CNMR
Acetamide(60-35-5)IR1
Acetamide(60-35-5)IR2
Acetamide(60-35-5)Raman
Acetamide(60-35-5)ESR
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

Acetamide, pure, 99%(60-35-5)
[Alfa Aesar]

Acetamide, 99%(60-35-5)
[Sigma Aldrich]

60-35-5(sigmaaldrich)
[TCI AMERICA]

Acetamide,>98.0%(GC)(60-35-5)
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