| Identification | More | [Name]
Thiocarbamide | [CAS]
62-56-6 | [Synonyms]
AKOS BBS-00004390
SULFOUREA
THIO
THIOCARBAMIDE
(NH2)2CS
2-Thiopseudourea
2-thio-ure
2-Thiourea
ai3-03582
beta-Thiopseudourea
caswellno855
epapesticidechemicalcode080201
Isothiourea
Pseudothiourea
Pseudourea, 2-thio-
Rcra waste number U219
rcrawastenumberu219
Sulfoharnstoff
Sulourea
Thiocarbamid | [EINECS(EC#)]
200-543-5 | [Molecular Formula]
CH4N2S | [MDL Number]
MFCD00008067 | [Molecular Weight]
76.12 | [MOL File]
62-56-6.mol |
| Chemical Properties | Back Directory | [Description]
Thiourea appears as white crystal/powder, is combustible, and on contact with fire, gives
off irritating or toxic fumes/gases. Thiourea is a reducing agent used primarily in the production
of bleached recycled pulp. In addition, it is also effective in the bleaching of stone
groundwood, pressurised groundwood. Thiourea undergoes decomposition on heating
and produces toxic fumes of nitrogen oxides and sulphur oxides. It reacts violently with
acrolein, strong acids, and strong oxidants. The main application of thiourea is in textile
processing and also is commonly employed as a source of sulphide. Thiourea is a precursor
to sulphide to produce metal sulphides, for example, mercury sulphide, upon reaction
with the metal salt in aqueous solution. The industrial uses of thiourea include production
of flame-retardant resins and vulcanisation accelerators. Thiourea is used as an auxiliary
agent in diazo paper, light-sensitive photocopy paper, and almost all other types
of copy paper. Thiourea is used in many industrial applications, including as a chemical
intermediate or catalyst, in metal processing and plating, and in photoprocessing. | [Appearance]
Thiourea consists of colorless, lustrous crystals or powder with a bitter taste. | [Melting point ]
171 °C | [Boiling point ]
263.89°C (estimate) | [density ]
1.405 | [refractive index ]
1.5300 (estimate) | [storage temp. ]
Store at RT. | [solubility ]
water: soluble137g/L at 20°C | [form ]
Crystals | [pka]
-1.0(at 25℃) | [color ]
White to almost white | [Specific Gravity]
1.406 | [Odor]
Odorless | [PH]
6-8 (50g/l, H2O, 20℃) | [PH Range]
5 - 7 | [Stability:]
Stable. Incompatible with strong acids, strong bases, strong oxidizing agents, metallic salts, proteins, hydrocarbons. May react violently with acrolein. | [Water Solubility ]
13.6 g/100 mL (20 ºC) | [Merck ]
14,9367 | [BRN ]
605327 | [Contact allergens]
Thiourea is used as a cleaner agent for silver and cop-
per, and as an antioxidant in diazo copy paper. It can
induce (photo-) contact dermatitis. | [InChIKey]
UMGDCJDMYOKAJW-UHFFFAOYSA-N | [LogP]
-1.050 (est) | [CAS DataBase Reference]
62-56-6(CAS DataBase Reference) | [IARC]
3 (Vol. Sup 7, 79) 2001 | [NIST Chemistry Reference]
Thiourea(62-56-6) | [EPA Substance Registry System]
62-56-6(EPA Substance) |
| Hazard Information | Back Directory | [Chemical Properties]
white crystals or powder | [Uses]
Chaotropic agent; strong denaturant. Increases solubility and recovery of proteins | [Uses]
The product is wildly used in pharmaceutical industry, agricultural, chemicals, metallurgical industry, petroleum and so on. It is also main material for producing thiourea dioxide(CH1N2O2S).
| [Uses]
Used in determination of bismuth. | [Definition]
ChEBI: The simplest member of the thiourea class, consisting of urea with the oxygen atom substituted by sulfur. | [Uses]
In animal glue liquifiers and silver tarnish removers. Photographic fixing agent and to remove stains from negatives; manufacture of resins; vulcanization accelerator; a reagent for bismuth, selenite ions. | [General Description]
White or off-white crystals or powder. Sinks and mixes with water. | [Reactivity Profile]
THIOUREA(62-56-6) is a white crystalline material or powder, toxic, carcinogenic. When heated to decomposition THIOUREA(62-56-6) emits very toxic fumes of oxides of sulfur and oxides of nitrogen. Violent exothermic polymerization reaction with acrylaldehyde (acrolein) [MCA SD-85, 1961], violent decomposition of the reaction product with hydrogen peroxide and nitric acid [Bjorklund G. H. et al., Trans. R. Soc. Can.,1950, 44, p. 28], spontaneous explosion upon grinding with potassium chlorate [Soothill, D., Safety Management, 1992, 8(6), p. 11]. | [Air & Water Reactions]
Water soluble. | [Health Hazard]
Poisonous inhaled or swallowed. Irritating to skin; may cause allergic skin eruptions. | [Potential Exposure]
Thiourea is used as rubber antiozonant, toning agent; corrosion inhibitor; and in pharmaceutical manufacture; in the manufacture of photosensitive papers; flame-retardant textile sizes; boiler water treatment. It is also used in photography; pesticide manufacture; in textile chemicals. | [First aid]
Move victim to fresh air. Call 911 or emergency medical service. Give artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. Medical observation is recommended for 24-48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy. | [Shipping]
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required. | [Incompatibilities]
Dust may form explosive mixture with air. Reacts violently with acrolein, strong acids (nitric acid). Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. | [Waste Disposal]
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. | [Preparation]
Thiourea is manufactured by heating ammonium thiocyanate at 140-145??C
for about 4 hours; equilibrium is established when about 25% of the
thiocyanate is converted to thiourea.Thiourea may also be prepared by the interaction of cyanamide and hydrogen sulphide:
Thiourea closely resembles urea in that reaction with formaldehyde gives
methylol derivatives and then resinous condensates which on continued
heating yield network structures. Thiourea-formaldehyde resins are slower
curing than urea-formaldehyde resins and the hardened products are more
brittle and more water-resistant. At one time thiourea-formaldehyde resins
were added to urea-formaldehyde resins to give mouldings and laminates
with improved water-resistance. These mixed resins have now been largely
superseded by melamine-formaldehyde resins which give products with better
resistance to heat. | [Production Methods]
Thiourea is formed by heating ammonium thiocyanate at 170 °C (338 °F). After about an hour, 25% conversion is achieved. With HCl, thiourea forms thiourea hydrochloride; with mercuric oxide, thiourea forms a salt; and with silver chloride, it forms a complex salt. | [Hazard]
A questionable carcinogen. May not be
used in food products (FDA); skin irritant (allergenic). | [Fire Hazard]
Noncombustible solid. There is no report of
any explosion resulting from reactions of
thiourea. Small amounts of thiourea in contact with acrolein may polymerize acrolein,
which is a highly exothermic reaction. | [Agricultural Uses]
Thiourea is a sulphur analogue of urea. It is a crystalline
and colorless solid which is relatively insoluble in water.
Thiourea, capable of breaking the dormancy of seeds, is
used to stimulate seed germination. Seeds are soaked for
less than 24 hours before planting. | [Biochem/physiol Actions]
Thiourea is a free radical scavenger of the peroxide radical. It was shown to inhibit lipid peroxidation and ultraviolet (UV)-induced crosslinking of collagen. Bud dormancy in plants can be inhibited by thiourea, which is used as a growth stimulator. It is also known to be used in the treatment of hyperthyroidism. | [Carcinogenicity]
Thiourea is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental
animals. | [Purification Methods]
Crystallise thiourea from absolute EtOH, MeOH, acetonitrile or water. Dry it under vacuum over H2SO4 at room temperature. [Beilstein 3 IV 342.] |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,N | [Risk Statements ]
R22:Harmful if swallowed.
R40:Limited evidence of a carcinogenic effect.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R63:Possible risk of harm to the unborn child. | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
2
| [RTECS ]
YU2800000
| [Autoignition Temperature]
440 °C Dust | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29309070 | [Hazardous Substances Data]
62-56-6(Hazardous Substances Data) | [Toxicity]
LD50 orally in wild Norway rats: 1830 mg/kg (Dieke) |
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