| Identification | More | [Name]
6-HYDROXYDOPAMINE HYDROBROMIDE | [CAS]
636-00-0 | [Synonyms]
2-(2,4,5-TRIHYDROXYPHENYL)ETHYLAMINE HYDROBROMIDE
2,4,5-TRIHYDROXYPHENETHYLAMINE HYDROBROMIDE
2,5-DIHYDROXYTYRAMINE HYDROBROMIDE
6-HYDROXYDOPAMINE HBR
6-HYDROXYDOPAMINE HYDROBROMIDE
2,4-benzenetriol,5-(2-aminoethyl)-hydrobromide
2,4,5-Trihydroxyphenethylamine
5-(2-aminoethyl)-4-hydroxypyrocatechol hydrobromide
6-Hydroxydopamine hydrbromide
6-HYDROXYDOPAMINE HYDROBROMIDE WITH ASCO RBIC ACID
KEMPTIDE, SYNTHETIC, >97% PURITY
6-Hydroxydopaminehydrobromide/ascorbicacid
6-HYDROXYDOPAMINE HYDROBROMIDE 99%
2,4,5-Trihydroxyphenethylamine hydrobromide, 2,5-Dihydroxytyramine hydrobromide, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrobromide, 6-OHDA
6-Hydroxydopamine·hydrogen bromide | [EINECS(EC#)]
211-247-0 | [Molecular Formula]
C8H12BrNO3 | [MDL Number]
MFCD00012894 | [Molecular Weight]
250.09 | [MOL File]
636-00-0.mol |
| Chemical Properties | Back Directory | [Appearance]
beige to brown fine crystalline powder | [Melting point ]
216-220 °C(lit.)
| [storage temp. ]
2-8°C
| [solubility ]
DMSO (Slightly), Methanol (Slightly), Water (Slightly) | [form ]
solid
| [color ]
tan to brown
| [BRN ]
3713280 | [Stability:]
Hygroscopic, Light Sensitive | [InChIKey]
MLACDGUOKDOLGC-UHFFFAOYSA-N | [CAS DataBase Reference]
636-00-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
DC4600000
| [F ]
3-10 |
| Hazard Information | Back Directory | [Description]
6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson''s disease in rodents.1 It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively.2 Intracisternal administration of 6-OHDA (200 μg) decreases dopamine (Item No. 21992) and norepinephrine (Item No. 16673) levels in rat brain.3 It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM.4,5 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB.5,6 | [Chemical Properties]
beige to brown crystalline powder | [Uses]
6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson''s disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells. | [General Description]
Solutions should be freshly prepared and protected from exposure to light. | [Biochem/physiol Actions]
Neurotoxin that destroys catecholaminergic terminals. | [storage]
Store at 4°C;, stored under nitrogen,unstable in solution, ready to use. |
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