ChemicalBook--->CAS DataBase List--->676-58-4

676-58-4

676-58-4 Structure

676-58-4 Structure
IdentificationMore
[Name]

Methylmagnesium chloride
[CAS]

676-58-4
[Synonyms]

METHYLMAGNESIUM CHLORIDE
chloromethyl-magnesiu
METHYLMAGNESIUM CHLORIDE, 2.5M SOLUTIONIN BUTYL DIGLYME
METHYLMAGNESIUM CHLORIDE, 3.0M SOLUTION IN TETRAHYDROFURAN
METHYLMAGNESIUM CHLORIDE SOLUTION, ~3 M IN THF
METHYLMAGNESIUM CHLORIDE, 3.0M SOLUTION
Methylmagnesium Chloride 1.5 M In Butyl Diglyme
Methylmagnesium Chloride 1.5 M in n-Butyl Ether
Methylmagnesium Chloride 2.0 M In Diethyl Ether
Methylmagnesium Chloride 2.0 M In Tetrahydrofuran
Methylmagnesium Chloride 2.2 M In Butyl Diglyme
Methylmagnesium Chloride 3.0 M In Tetrahydrofuran
Methylmagnesiumchloride,3MinTHF
Methylmagnesium chloride, 22 wt% solution in tetrahydrofuran
METHYLMAGNESIUM CHLORIDE, 3 M in TETRAHYDROFURAN
METHYLMAGNESIUM CHLORIDE IN TFE
Magnesium, chloromethyl-
methylmagnesium chloride solution
methylmagnesium chloride, 3m in thf, packaged under argon in resealable chemseal
Methylmagnesium chloride, 3M in THF, packaged under Argon in resealable ChemSealTM bottles
[EINECS(EC#)]

211-629-7
[Molecular Formula]

CH3ClMg
[MDL Number]

MFCD00000468
[Molecular Weight]

74.79
[MOL File]

676-58-4.mol
Chemical PropertiesBack Directory
[Definition]

Available as a solutionin tetrahydrofuran.
[Appearance]

dark brown solution
[Boiling point ]

66 °C
[density ]

1.013 g/mL at 25 °C
[Fp ]

−1 °F
[storage temp. ]

Flammables + water-Freezer (-20°C)e area
[solubility ]

Miscible with diethyl ether and tetrahydrofuran.
[form ]

Liquid
[color ]

Pale brown to dark green
[Water Solubility ]

reacts
[Sensitive ]

Air & Moisture Sensitive
[BRN ]

3587199
[Exposure limits]

ACGIH: TWA 50 ppm; STEL 100 ppm (Skin)
OSHA: TWA 200 ppm(590 mg/m3)
NIOSH: IDLH 2000 ppm; TWA 200 ppm(590 mg/m3); STEL 250 ppm(735 mg/m3)
[Uses]

Alkylating agent in organic synthesis, Grignardreagent.
[CAS DataBase Reference]

676-58-4(CAS DataBase Reference)
[Storage Precautions]

Store under inert gas;Moisture sensitive;Air sensitive
[EPA Substance Registry System]

676-58-4(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

F,C
[Risk Statements ]

R11:Highly Flammable.
R14/15:Reacts violently with water, liberating extremely flammable gases .
R34:Causes burns.
R19:May form explosive peroxides.
R15:Contact with water liberates extremely flammable gases.
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S30:Never add water to this product .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S43:In case of fire, use ... (indicate in the space the precise type of fire-fighting equipment. If water increases the risk add-Never use water) .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S7/8:Keep container tightly closed and dry .
S33:Take precautionary measures against static discharges .
S29:Do not empty into drains .
S16:Keep away from sources of ignition-No smoking .
[RIDADR ]

UN 3399 4.3/PG 2
[WGK Germany ]

1
[F ]

1-3-10
[Autoignition Temperature]

609 °F
[TSCA ]

Yes
[HazardClass ]

4.3
[PackingGroup ]

I
[HS Code ]

29319090
[Hazardous Substances Data]

676-58-4(Hazardous Substances Data)
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Methylmagnesium chloride (676-58-4).msds
Hazard InformationBack Directory
[Hazard]

Flammable, dangerous fire and explosionrisk.
[Chemical Properties]

dark brown solution
[Application]

Methylmagnesium chloride solution (3 M in THF) undergoes 1,3-addition with dialdose derived nitrones to form N-benzylhydroxylamines. The reductive cleavage of the N-O bond of these N-benzylhydroxylamines results in N-benzylaminosugars, which are key moieties of bioactive compounds. It can also react with Garner type aldehydes to form the corresponding secondary alcohols.
[Preparation]

reaction of methyl chloride and magnesium in anhydrous diethyl ether, usually in the presence of an initiator.
[Reactions]

Methylmagnesium chloride can react with acidic hydrogen on oxygen, sulfur and alkyne carbon of compounds containing active hydrogen (such as water, alcohol, mercaptan, amine, amide, acid, sulfonic acid, etc.); Propyl bromide, etc.) undergoes a coupling reaction; it can react with oxygen and carbon dioxide, aldehydes, ketones, etc.
Well-known Reagent Company Product InformationBack Directory
[Acros Organics]

Methylmagnesium chloride, 22 wt% solution in tetrahydrofuran, AcroSeal?(676-58-4)
[Alfa Aesar]

Methylmagnesium chloride, 3M in THF, packaged under Argon in resealable ChemSeal™ bottles(676-58-4)
[Sigma Aldrich]

676-58-4(sigmaaldrich)
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