| Identification | More | [Name]
1-Amino-4-methylpiperazine | [CAS]
6928-85-4 | [Synonyms]
1-AMINO-4-METHYLPIERAZINE
1-AMINO-4-METHYLPIPERAZINE
1-METHYL-4-AMINOPIERAZINE
1-METHYL-4-AMINOPIPERAZINE
4-AMINO-1-METHYLPIPERAZINE
4-methylpiperazin-1-ylamine
AMPRZ
LABOTEST-BB LT00005082
N-METHYL-N-AMINOPIPERAZINE
TIMTEC-BB SBB004299
1-Piperazinamine, 4-methyl-
4-Methyl-1-piperazinamine
4-methylpiperazin-1-amine
AMINOMETHYLPIPERAZINE
1-Amino-4-Methyl
1-METHYL-4-AMINOPIPERAZINE(1-AMINO-4-METHYLPIPERAZINE)
1-Amino-4-methylpiperazine ,98%
1-Methylpiperazine-4-amine
4-Methyl-1-aminopiperazine | [EINECS(EC#)]
230-053-7 | [Molecular Formula]
C5H13N3 | [MDL Number]
MFCD00006154 | [Molecular Weight]
115.18 | [MOL File]
6928-85-4.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to light yellow liquid | [Boiling point ]
172-175 °C (lit.) | [density ]
0.957 g/mL at 25 °C(lit.) | [vapor pressure ]
1.29hPa at 25℃ | [refractive index ]
1.4835-1.4855
| [Fp ]
62 °C
| [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
water: soluble | [form ]
Viscous Solution | [pka]
7?+-.0.42(Predicted) | [color ]
Clear | [Water Solubility ]
miscible | [Sensitive ]
Air & Light Sensitive | [BRN ]
103334 | [InChIKey]
RJWLLQWLBMJCFD-UHFFFAOYSA-N | [CAS DataBase Reference]
6928-85-4(CAS DataBase Reference) | [NIST Chemistry Reference]
1-Amino-4-methylpiperazine(6928-85-4) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
2733 | [WGK Germany ]
3 | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29335995 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to light yellow liquid | [Uses]
1-Amino-4-methylpiperazine has been used:
- in synthesis of pyrazolo-pyrazine, -pyridine derivatives and 2-[(4-methylpiperazin-1-yl)iminomethyl]phenol
- as a solvating and stabilizing agent in the preparation of uniform Ag nanoparticles (<10nm)
| [Application]
1-Amino-4-methylpiperazine, a derivative of piperazine, is used widely as an intermediate in the synthesis of pharmaceutical agents. It is an important intermediate for Rifampicin. Rifampicin , known as rifampin, is an antibiotic used to treat a several kinds of bacterial infections such as tuberculosis, leprosy and Legionnare's disease. | [Preparation]
1-Amino-4-methylpiperazine is obtained from piperazine hexahydrate through the steps of methylation, hydrolysis, nitrosation and reduction.
1-Amino-4-methylpiperazine is synthesized by chlorination of methyl(diethanol)amine (I) and subsequent cyclization of the di(chloroethyl)amine (II) obtained in aqueous hydrazine. | [Flammability and Explosibility]
Notclassified |
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