101189-47-3

中文名称 101189-47-3

英文名称 2-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole

CAS 101189-47-3

分子式 C13H20N6S

分子量 292.4

MOL 文件 101189-47-3.mol

101189-47-3 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T15005

英文别名

CP-66,948
2-(N-Pentyl-N'-guanidino)-4-(2-methylimidazol-4-yl)thiazole
Guanidine, N-[4-(2-methyl-1H-imidazol-5-yl)-2-thiazolyl]-N'-pentyl-
1-[4-(2-methyl-1H-imidazol-5-yl)-1,3-thiazol-2-yl]-2-pentylguanidine

物理化学性质

沸点517.0±42.0 °C(Predicted)

密度1.34±0.1 g/cm3(Predicted)

储存条件-20°C储存

溶解度溶于二甲基亚砜

酸度系数(pKa)11.38±0.10(Predicted)

常见问题列表

生物活性

CP-66948 是 histamine H2 受体拮抗剂，能够抑制胃酸分泌，保护粘膜的作用。

体内研究

The affinity of CP-66,948 for the guinea pig atria histamine H2-receptor is 15 times greater than that of cimetidine and seven times greater than that of ranitidine. In vivo, the ED ₅₀ value for inhibition of gastric acid secretion in pylorus-ligated rats is 2 mg/kg intraduodenally, and in histamine or pentagastrin-stimulated Heidenhain pouch dogs the antisecretory ED ₅₀ values are 0.3 mg/kg per os and 1.0 mg/kg per os, respectively. CP-66,948 also inhibits ethanol-induced gastric hemorrhagic lesions in rats following either oral or systemic administration (ED ₅₀ values of 12 mg/kg per os and 6 mg/kg subcutaneously).