基本信息
中文别名
化合物 T27164 英文别名
PAK9PAK 9
PAK-9
DHP 218
2-[1,4-Dihydro-2,6-dimethyl-3-(methoxycarbonyl)-4-(2-nitrophenyl)pyridin-5-yl]-1,3,2-dioxaphosphorinane 2-oxide
应用领域
用途一
DHP-218, also known as PAK-9, is a calcium channel antagonist potentially for the treatment of hypertension and myocardia ischemia. Calcium-induced contraction of the rat aorta in high K+ solution was inhibited by DHP-218 with the pA2 value of 9.11. The IC50 value for the inhibitory effects of this compound in high K+-induced and phenylephrine-induced contraction was 6.3 nmol/l and 66 nmol/l, respectively.