110417-88-4
中文名称
DOLASTATIN 10
英文名称
dolastatin 10
CAS
110417-88-4
分子式
C42H68N6O6S
分子量
785.09
MOL 文件
110417-88-4.mol
更新日期
2024/05/25 01:14:35
110417-88-4 结构式
基本信息
中文别名
尾海兔素10尾海兔素10, >99%
微管蛋白聚合抑制剂(DOLASTATIN 10)
英文别名
DLS 10CS-1367
Nsc376128
Dolastain10
B720389K560
dolastatin 10
Dolastatin 10 (NSC-376128)
From dolabella auricularia (sea hare)
Dolastatin 10,DLS 10,NSC 376128, >99%
6-[bis[2-[(2-methylpropan-2-yl)oxycarbonylamino]ethyl] amino]-6-oxohexanoic acid
所属类别
生物化工：激动剂抑制剂物理化学性质
沸点903.6±65.0 °C(Predicted)
密度1.116±0.06 g/cm3(Predicted)
储存条件Store at -20°C,unstable in solution, ready to use.
溶解度≥78.5 mg/mL in EtOH; insoluble in H2O; ≥67.2 mg/mL in DMSO
酸度系数(pKa)13.81±0.46(Predicted)
形态粉末
常见问题列表
生物活性
Dolastatin 10 (DLS 10) 是一种有效的从海洋软体动物Dolabela auricularia中分离出来的抗有丝分裂肽，抑制微管蛋白聚合。靶点
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Auristatin
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体外研究
Dolastatin 10 is a unique pentapeptide that isolated from the sea hare Dolabella auricularia . These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI 50 values of 10 −5 -10 −6 μg/mL (10 −2 -10 −3 nM) against a similar minipanel of human cell lines. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10.