1123231-07-1
中文名称
MAY-262611
英文名称
MAY-262611
CAS
1123231-07-1
分子式
C20H22N4
分子量
318.42
MOL 文件
1123231-07-1.mol
更新日期
2024/05/08 13:16:09
1123231-07-1 结构式
基本信息
中文别名
WAY-262611游离态Β-联蛋白激动剂(WAY-262611)
1-[4-(2-萘基)-2-嘧啶基]-4-哌啶甲胺
英文别名
DKK1CS-1296
MAY-262611
WAY-262611
Wnt/β-catenin
WAY262611
WAY 262611
Human DKK1 Protein, His Tag
Recombinant Mouse Dkk-1 Protein, 8*His Tag
Recombinant Human DKK-1/DKK1 Protein, 8* His Tag
1-[4-(2-Naphthalenyl)-2-pyrimidinyl]-4-piperidinemethanamine
所属类别
生物化工：激动剂抑制剂物理化学性质
沸点544.8±42.0 °C(Predicted)
密度1.169±0.06 g/cm3(Predicted)
储存条件Keep in dark place,Inert atmosphere,2-8°C
溶解度DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 50 mg/ml; Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
酸度系数(pKa)10.13±0.29(Predicted)
形态粉末
常见问题列表
生物活性
WAY-262611是 Wnt/β- 联蛋白激动剂，可增加骨形成速率，在 TCF- 荧光素酶测定实验中的 EC50 值为0.63 μM。WAY-262611 也是 Dkk1 的抑制剂。靶点
EC50: 0.63 μM (β-Catenin)
体外研究
WAY-262611 has the most potent activity in the primary assay, low kinase inhibition potential, and high solubility.
体内研究
WAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration. Calvariae from wt mice treated with WAY-262611 shows statistically increased BFR, while similarly treated KO animals are no different from control. This indicates that WAY-262611 is acting via the Wnt β -catenin pathway and most likely through inhibition of Dkk-1.