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1135237-88-5

中文名称 EXHERIN
英文名称 Exherin (trifluoroacetate)
CAS 1135237-88-5
分子式 C24H35F3N8O8S2
分子量 684.709
MOL 文件 1135237-88-5.mol
更新日期 2024/05/05 20:58:32
1135237-88-5 结构式 1135237-88-5 结构式

基本信息

中文别名
ADH-1三氟乙酸盐
化合物EXHERIN TRIFLUOROACETATE
英文别名
ADH-1 trifluroacetate
ADH-1 TRIFLUOROACETATE
Exherin (trifluoroacetate)
所属类别
生物化工:激动剂抑制剂

物理化学性质

储存条件-20°C储存
溶解度DMSO:43.0(Max Conc. mg/mL);62.8(Max Conc. mM)
EXHERIN价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/04/30HY-13541AEXHERIN
ADH-1 trifluoroacetate
1135237-88-55mg1100元
2024/04/30HY-13541AEXHERIN
ADH-1 trifluoroacetate
1135237-88-510mM * 1mLin DMSO1657元
2024/04/30HY-13541AEXHERIN
ADH-1 trifluoroacetate
1135237-88-510mg1800元

常见问题列表

生物活性
ADH-1 trifluoroacetate是选择性和竞争性的N-钙粘蛋白拮抗剂,具有潜在抗肿瘤和抗血管生成活性。
体外研究

ADH-1 (0.2 mg/mL) blocks collagen I-mediated changes in pancreatic cancer cells, and is highly effective at preventing cell motility that is induced by expression of N-cadherin. ADH-1 (0, 0.1, 0.2, 0.5 and 1.0 mg/mL) induces apoptosis in a dose-dependent and N-cadherin-dependent manner.

体内研究

ADH-1 (50 mg/kg) significantly prevents tumor growth and metastasis in a mouse model for pancreatic cancer. ADH-1 prevents tumor cell invasion and metastasis in an orthotopic model for pancreatic cancer using N-cadherin overexpressing BxPC-3 cells. ADH-1, at the dosages evaluated, does not display either antiangiogenic activity in a rat aortic ring assay or antitumor potential in a PC3 subcutaneous xenograft tumor model. ADH-1 (10 mL/kg, i.p.) augmentation of melanoma tumor growth is overcome through its ability to make regionally infused melphalan more effective. ADH-1 mediated augmentation of melanoma tumor growth is not altered by regionally infused temozolomide. In A375, but not DM443 xenografts, ADH-1 treatment increases phosphorylation of AKT at serine 473. ADH-1 slightly diminishes N-cadherin expression in both xenografts.

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