1137359-47-7

中文名称 BRD7552

英文名称 ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate

CAS 1137359-47-7

分子式 C33H33N3O15

分子量 711.63

MOL 文件 1137359-47-7.mol

更新日期 2024/04/08 11:57:24

1137359-47-7 结构式

基本信息物理化学性质图谱信息 BRD7552价格(试剂级) 常见问题列表

基本信息

中文别名

4-(((((2R,3R,4S,5R,6S)-4,5-双((苯并[D][1,3]二氧戊环-5-基氨基甲酰基)氧基)-2-(羟甲基)-6-甲氧基四氢-2H-吡喃-3-基)氧基)羰基)氨基)苯甲酸乙酯

英文别名

CS-1560
BRD7552
BRD7552 >=98% (HPLC)
BRD 7552
BRD-7552
BRD7552
Methyl [2,3-O-bis(Benzo[1,3]dioxol-5-yl-carbamoyl)]-4-O-(4-ethoxycarbonyl-phenylcarbamoyl)-α-D-glucopyranoside
α-D-Glucopyranoside, methyl, 2,3-bis(N-1,3-benzodioxol-5-ylcarbamate) 4-[N-[4-(ethoxycarbonyl)phenyl]carbamate]
ethyl 4-(((2R,3R,4S,5R,6S)-4,5-bis(benzo[d][1,3]dioxol-5-ylcarbamoyloxy)-2-(hydroxymethyl)-6-methoxy-tetrahydro-2H-pyran-3-yloxy)carbonyl)benzoate

所属类别

生物化工：激动剂抑制剂

物理化学性质

沸点757.6±60.0 °C(Predicted)

密度1.53±0.1 g/cm3(Predicted)

储存条件-20°C储存

溶解度DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.2 mg/ml; DMSO: 20 mg/ml; Ethanol: 10 mg/ml

酸度系数(pKa)11.81±0.20(Predicted)

形态结晶固体

图谱信息

BRD7552(1137359-47-7)质谱(MS)

BRD7552价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-19694	BRD7552 BRD7552	1137359-47-7	5mg	880元
2024/04/30	HY-19694	BRD7552 BRD7552	1137359-47-7	10mg	1250元
2024/04/30	HY-19694	BRD7552 BRD7552	1137359-47-7	50mg	4500元

常见问题列表

生物活性

BRD7552 是一种 PDX1 转录因子诱导剂，它上调了人类原代胰岛和导管细胞中 PDX1 的表达，并诱导 PDX1 启动子的表观遗传变化与转录激活一致。BRD7552 增加胰岛素表达。PDX1 是参与胰腺发育和β细胞功能的关键转录因子。

体外研究

BRD7552 (0-5 μM; 5 days) induces a dose-dependent increase in PDX1 protein levels after BRD7552 treatment in PANC-1 cells.
BRD7552 acts in a FOXA2-dependent manner to increase PDX1 expression in human ductal cells. Nine-day treatment of PANC-1 cells with BRD7552 (0-10 μM) causes a dose-dependent increase in insulin mRNA expression. BRD7552 induces insulin expression in PANC-1 cells. BRD7552 increases H3 acetylation and H3K4me3 and decreases H3K9me3, results that are consistent with transcriptional activation of PDX1. The epigenetic changes induced by BRD7552 are consistent with transcriptional activation, and BRD7552 acts in a FOXA2-dependent manner.

Western Blot Analysis

Cell Line:	PANC-1 cells
Concentration:	1.25, 2.5, 5 μM
Incubation Time:	5 days
Result:	Induced a dose-dependent increase in PDX1 protein levels.