1146702-54-6
中文名称
CAL-101
英文名称
CAL-101
CAS
1146702-54-6
分子式
C22H18FN7O
分子量
415.423
MOL 文件
1146702-54-6.mol
更新日期
2024/05/20 09:19:54
1146702-54-6 结构式
基本信息
中文别名
艾代拉里斯杂质艾代拉里斯杂质A
英文别名
IdelalisibGS-1101, Idelalisib
CAL-101 (GS-1101, Idelalisib)
5-fluoro-3-phenyl-2-((1s)-1-(1h-purin-6-ylamino)ethyl)-4(3h)...
应用领域
用途一
Idelalisib is an orally available selective and potent phosphatidylinositol
3-kinase δ (PI3 Kδ) inhibitor originally developed
by Calistoga Pharmaceuticals, which was acquired by Gilead in
April 2014. In July 2014, the drug was approved in the USA for
the treatment of relapsed chronic lymphocytic leukemia as well
as several oncology orphan drug designations. Since idelalisib
specifically inhibits PI3Kd, which is expressed primarily in bloodcell
lineages, the therapeutic effect is localized, limiting interference
with PI3K isoform signaling that is critical to normal function
of healthy cells.