1155877-97-6
中文名称
D159687
CAS
1155877-97-6
分子式
C21H19ClN2O2
分子量
366.84
MOL 文件
1155877-97-6.mol
更新日期
2024/05/07 11:47:11
1155877-97-6 结构式
基本信息
英文别名
D159687D159687
D-159687
D 159687
1-(4-((3'-chloro-6-methoxybiphenyl-3-yl)methyl)phenyl)urea
1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea
Urea, N-[4-[(3'-chloro-6-methoxy[1,1'-biphenyl]-3-yl)methyl]phenyl]-
物理化学性质
沸点502.0±50.0 °C(Predicted)
密度1.263±0.06 g/cm3(Predicted)
储存条件Sealed in dry,Room Temperature
酸度系数(pKa)14.48±0.50(Predicted)
D159687价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-15444 | D159687 D159687 | 1155877-97-6 | 5mg | 600元 |
| 2024/04/30 | HY-15444 | D159687 D159687 | 1155877-97-6 | 10mM * 1mLin DMSO | 660元 |
| 2024/04/30 | HY-15444 | D159687 D159687 | 1155877-97-6 | 25 mg | 2010元 |
常见问题列表
生物活性
D159687 是一种选择性 PDE4D 抑制剂。靶点
PDE4D
体外研究
D159687 (1 μM, 0-24 hours) induces a transient increase in CREB phosphorylation which peaked at 6 hours after treatment.
D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1 μM.
Western Blot Analysis
| Cell Line: | HT-22 (mouse hippocampal cell line) |
| Concentration: | 1 μM |
| Incubation Time: | 0, 1, 3, 6, 12, 24 hours |
| Result: | Induced a transient increase in CREB phosphorylation which peaked at 6 hours after treatment. |
Western Blot Analysis
| Cell Line: | HT-22 (mouse hippocampal cell line) |
| Concentration: | 0.01 μM, 0.1 μM, 1 μM |
| Incubation Time: | 6 hours |
| Result: | CREB phosphorylation was optimal at 1 μM. |
体内研究
D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques.
| Animal Model: | Female Cynomolgus macaques (4–6 year old) |
| Dosage: | 0.05, 0.5, 5 mg/kg |
| Administration: | Oral daily for a week |
| Result: | A potential recruitment or enhancement of synaptic function with increased task difficulty. |