120447-62-3

中文名称 (+/-)-VESAMICOL HYDROCHLORIDE

英文名称 (+/-)-VESAMICOL HYDROCHLORIDE

CAS 120447-62-3

分子式 C17H26ClNO

分子量 295.85

MOL 文件 120447-62-3.mol

120447-62-3 结构式

基本信息物理化学性质安全数据图谱信息常见问题列表

基本信息

中文别名

盐酸扎氟普汀
化合物 T22486

英文别名

AH-5183
(+/-)-VESAMICOL HCL
AH-5183 HYDROCHLORIDE
(±)-VesamicolHCl (AH-5183)
rel-Vesamicol Hydrochloride
(+/-)-VESAMICOL HYDROCHLORIDE
(+/-)-VesamicolmiddotHCl(AH-5183)
(+/-)-VESAMICOL HYDROCHLORIDE (AH-5183) >98%
Ah-5183((+/-)-2-(4-phenylpiperidino) cyclohexanol
(+/-)-2-(4-PHENYLPIPERIDINO)CYCLOHEXANOL HYDROCHLORIDE

物理化学性质

储存条件Store at RT

溶解度aqueous buffers below pH 8: 1 mM

形态solid

颜色white

安全数据

WGK Germany3

图谱信息

(+/-)-VESAMICOL HYDROCHLORIDE(120447-62-3)核磁图(¹HNMR)

常见问题列表

生物活性

(±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) 是一种有效的囊泡乙酰胆碱转运 (vesicular acetylcholine transport) 抑制剂，Ki 为 2 nM。(±)-Vesamicol hydrochloride 也对 σ1 和 σ2 受体具有高亲和力，Ki 值分别为 26 nM 和 34 nM。

靶点

Ki: 2 nM (Vesicular acetylcholine transport), 26 nM (σ1 receptors) and 34 nM (σ2 receptors)

体外研究

The pharmacological actions of (±)-Vesamicol have been attributed to inhibition of acetylcholine transport into synaptic vesicles and the subsequent quantal release of acetylcholine.

体内研究

(±)-Vesamicol (3 mg/kg; intraperitoneal injection; once; male Wistar rats) treatment increases the levels of cytosolic acetylcholine (ACh) in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum.

Animal Model:	Male Wistar rats (120-300 g)
Dosage:	3 mg/kg
Administration:	Intraperitoneal injection; once
Result:	The levels of cytosolic acetylcholine (ACh) increased in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum.