1218816-71-7
中文名称
1218816-71-7
英文名称
(2S,3S)-N-((S)-1-(4-(5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)-3-hydroxypyrrolidine-2-carboxamide
CAS
1218816-71-7
分子式
C22H30N4O3
分子量
398.5
MOL 文件
1218816-71-7.mol
1218816-71-7 结构式
基本信息
中文别名
鞘氨醇激酶1(SPHK1)抑制剂(SK1-IN-1) 英文别名
SK1-IN-1SK1 inhibitor 1
(2S,3S)-N-((S)-1-(4-(5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl)phenyl)ethyl)-3-hydroxypyrrolidine-2-carboxamide
2-Pyrrolidinecarboxamide, N-[(1S)-1-[4-[5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl]phenyl]ethyl]-3-hydroxy-, (2S,3S)-
常见问题列表
生物活性
SK1-IN-1是一种有效的鞘氨醇激酶1 (SPHK1) 抑制剂，IC50 值为58 nM。靶点
IC50: 58 nM (SPHK1)
体内研究
SK1-IN-1 demonstrates significant improvement in the intrinsic clearance, particularly against human liver microsomes. SK1-IN-1 is selected for rat PK studies and demonstrates modest in oral bioavailability with acceptable half-lives in blood circulation.