13116-77-3
13116-77-3 结构式
基本信息
中文别名
化合物 T12265 英文别名
NSC-624206N-[3-(4-chlorophenyl)-3,3-disulfanylpropyl]decan-1-aminium chloride
N-[2-[[(4-Chlorophenyl)methyl]dithio]ethyl]-1-decanamine hydrochloride
常见问题列表
生物活性
NSC624206 是一种泛素 E1 (UBA1) 抑制剂，其 IC50 值为 ~9 μM。NSC624206 特异性地阻断泛素-硫代酯的形成，但对泛素腺化无影响。靶点
IC50: ~9 μM (ubiquitin E1)
体外研究
NSC624206 prevents in vitro ubiquitination of the cell cycle regulator p27 as well as inducing an accumulation of p27 in the HepG2 liver cancer cell line.
NSC624206 clearly reduces ubiquitin-E1 thioesters in a concentration-dependent manner with an IC
50
of 13 μM.
NSC624206 (10 nM-10 μM; 24 hours) induces accumulation of p27 in cells.
Western Blot Analysis
| Cell Line: | Kip16 cells |
| Concentration: | 10 nM-10 μM |
| Incubation Time: | 24 hours |
| Result: | Induced accumulation of p27. |