156722-18-8

中文名称 ROSTAFUROXIN

英文名称 (3S,5R,8R,9S,10S,13R,14S,17R)-17-(3-furyl)-10,13-dimethyl-2,3,4,5,6,7, 8,9,11,12,15,16-dodecahydro-1H-cyclopenta[a]phenanthrene-3,14,17-triol

CAS 156722-18-8

分子式 C23H34O4

分子量 374.51

MOL 文件 156722-18-8.mol

更新日期 2024/04/28 11:56:10

156722-18-8 结构式

基本信息物理化学性质图谱信息 ROSTAFUROXIN价格(试剂级) 常见问题列表

基本信息

中文别名

(3Β,?5Β,?14Β)?-?21,23-环氧-24-降胆固醇-20,22-二烯-3,14,17-三醇

英文别名

CS-906
PST2238
17-triol
AC1L4BGU
Rostafuroxin
CHEMBL2068971
SureCN1716210
UNII-P848LCX62B
PST 2238, >=98%
PST2238,Rostafuroxin

所属类别

生物化工：激动剂抑制剂

物理化学性质

沸点451.3±45.0 °C(Predicted)

密度1.226±0.06 g/cm3(Predicted)

储存条件Sealed in dry,Store in freezer, under -20°C

溶解度insoluble in H2O; insoluble in EtOH; ≥12.05 mg/mL in DMSO

酸度系数(pKa)14.02±0.70(Predicted)

形态固体

图谱信息

ROSTAFUROXIN(156722-18-8)核磁图(¹HNMR)

ROSTAFUROXIN价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-12283	ROSTAFUROXIN Rostafuroxin	156722-18-8	5mg	750元
2024/04/30	HY-12283	ROSTAFUROXIN Rostafuroxin	156722-18-8	10mM * 1mLin DMSO	830元
2024/04/30	HY-12283	ROSTAFUROXIN Rostafuroxin	156722-18-8	10mg	1350元

常见问题列表

生物活性

Rostafuroxin (PST 2238) 是一种洋地黄毒苷衍生物，一种口服有效的 Na+,K+-ATPase (ATP1A1) 抑制剂。Rostafuroxin 与 ATP1A1 胞外域特异性结合，并阻断呼吸道合胞病毒 (RSV) 触发的 EGFR Tyr845 磷酸化。Rostafuroxin 具有抗高血压和抗 RSV 活性。

体外研究

Rostafuroxin (PST 2238) competitively inhibits Ouabain (HY-B0542) binding and signaling. Rostafuroxin antagonizes the molecularand functional effects of Ouabain by reversing the ouabain-induced, Src-dependent Na ⁺ ,K ⁺ -ATPase phosphorylation and activation.
Rostafuroxin (0.125-128 μM; for 24 h post treatment) has less than 20% reduction in cell viability in A549 cells and HSAEC. Rostafuroxin inhibits the expression of RSV-GFP in HSAEC (IC ₅₀ =1.8 μM) and A549 cells (IC ₅₀ =14.8 μM).
Rostafuroxin displaced [ ³ H]Ouabain from the dog kidney Na ⁺ ,K ⁺ -ATPase receptor (IC50=1.5 nM), is devoid of cardiac inotropic activity in isolated guinea pig atria, and shows no affinity up to 10 ^-4 M with general (R1, R2, a1, a2, A1, A2, M1, M2, H1, H2, 5-HT1, 5-HT2, Ca2+ channels, TXA2/PGH2, PAF, GABAA, GABAB, DA-NE-5-HT uptake, glutammate,glycine, benzodiazepine) and hormonal (estrogenic, progestinic, androgenic, mineralcorticoid) receptors.

体内研究

Rostafuroxin (PST 2238; 1 mg/kg/day; gavage; for 3 weeks) decreases SBP and improves acetylcholine-induced relaxation.

Animal Model:	Male 7-week-old Wistar rats
Dosage:	1 mg/kg
Administration:	Gavage; daily; for 3 weeks
Result:	Decreased SBP, improved acetylcholine-induced relaxation via enhanced nitric oxide synthesis and bioavailability, decreased superoxide anion generation from NAD(P)H oxidase and cyclooxygenase-2 and reduced cytoplasmic tyrosine kinase Src phosphorylation.