159138-80-4
159138-80-4 结构式
基本信息
N-(氨基亚氨基甲基)-4-(1-甲基乙基)-3-(甲磺酰基)苯甲酰胺
CARIPORIDE
Cariporide (HOE-642)
N-(diaminomethylene)-4-isopropyl-3-mesyl-benzamide
N-(Aminoiminomethyl)-4-(1-methylethyl)-3-(methylsulfonyl)benzamide
N-[bis(azanyl)methylidene]-3-methylsulfonyl-4-propan-2-yl-benzamide
BenzaMide,N-(aMinoiMinoMethyl)-4-(1-Methylethyl)-3-(Methylsulfonyl)-
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-19693 | 卡立泊来德 Cariporide | 159138-80-4 | 5mg | 550元 |
| 2024/04/30 | HY-19693 | 卡立泊来德 Cariporide | 159138-80-4 | 10mM * 1mLin DMSO | 605元 |
| 2024/04/30 | HY-19693 | 卡立泊来德 Cariporide | 159138-80-4 | 10mg | 770元 |
常见问题列表
| Target | Value |
|
NHE1
(CHO-K1 cells) | 30 nM |
Cariporide significantly suppresses markers of cell death, such as TUNEL positivity and caspase-3 cleavage, at 8 or 16 hours. Cariporide remarkably suppresses cytosolic Na + and Ca 2+ accumulation. Cariporide prevents mitochondrial membrane potential loss induced by H 2+ O 2+ . Cariporide (HOE-642) ameliorates myocardial ischemia/reperfusion injury, by the well-established reduction of cytosolic Ca 2+ in cardiac myocytes through inhibition of Na + /H + exchange. Cariporide (HOE-642), has inhibitory effects on the degranulation of human platelets, the formation of platelet–leukocyte-aggregates, and the activation of the GPIIb/IIIa receptor (PAC-1).
Intravenous administration of cariporide significantly decreases brain Na + uptake and reduces cerebral edema, brain swelling, and infarct volume.