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160434-48-0

中文名称 4-去甲基异氟烷
英文名称 4-DesMethyl Istradefylline
CAS 160434-48-0
分子式 C19H22N4O4
分子量 370.4
MOL 文件 160434-48-0.mol
更新日期 2024/03/08 11:56:33
160434-48-0 结构式 160434-48-0 结构式

基本信息

中文别名
伊曲茶碱杂质14
4-去甲基伊曲茶碱
英文别名
4-DesMethyl Istradefylline
Istradefylline Impurity 14
Istradefylline M1 metabolite
4-DesMethyl Istradefylline impurity
Istradefylline 4-O-Desmethyl Impurity
(E)-1,3-diethyl-8-(4-hydroxy-3-methoxystyryl)-7-methyl-1H-purine-2,6(3H,7H)-dione
1H-Purine-2,6-dione, 1,3-diethyl-3,7-dihydro-8-[2-(4-hydroxy-3-methoxyphenyl)ethenyl]-7-methyl-, (E)- (9CI)

应用领域

用途1
4-Desmethyl Istradefylline is an impurity of Istradefylline (I927000), a selective A(2A) antagonist used in the treatment of Parkinson鈥檚 disease. 4-Desmethyl Istradefylline have also been shown to exh ibit inhibitory potency towards adenosine A2A receptors and is classified as its an adenosine A2A receptor antagonist.

常见问题列表

生物活性
4-Desmethyl Istradefylline 是 Istradefylline 的代谢物。Istradefylline 是一种有效的,选择性的,可口服的 adenosine A2A receptor 拮抗剂,在帕金森疾病模型试验中,Ki 值为 2.2 nM。
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