1627709-94-7
中文名称
LJI308
英文名称
LJI308
CAS
1627709-94-7
分子式
C21H18F2N2O2
分子量
368.38
MOL 文件
1627709-94-7.mol
更新日期
2024/05/21 15:12:59
1627709-94-7 结构式
基本信息
中文别名
RSK抑制剂(LJI308) 英文别名
LJI308CS-2181
LJI 308
LJI308
LJI308 >=98% (HPLC)
LJI-308
LJI 308
LJI308
2,6-Difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]phenol
Phenol, 2,6-difluoro-4-[4-[4-(4-morpholinyl)phenyl]-3-pyridinyl]-
所属类别
生物化工：激动剂抑制剂
常见问题列表
生物活性
LJI308 是一种有效的泛 RSK 抑制剂，对 RSK1、RSK2 和 RSK3 的 IC50 分别为 6 nM、4 nM 和 13 nM。LJI308 抑制辐照、EGF 处理和 表达 KRAS 突变的细胞中 RSK (T359/S363) 和 YB-1 (S102) 的磷酸化。体外研究
LJI308 inhibits S6K1 with an IC
50
of 0.8 μM.
LJI308 inhibits YB-1 phosphorylation in CRC cells at concentrations of 5 to 25 μM. In a dose kinetics experiment, LJI308, starting at 2.5 μM, inhibits YB-1 phosphorylation in the KRAS mutated TNBC cell line MDA-MB-231 by approximately 86%. LJI308 effectively blocks RSK and YB-1 phosphorylation after EGF stimulation and after irradiation in KRAS wild-type HBL-100 cells.
LJI308 (1-10 μM; 96 hours) decreases cell viability by up to 90%.
Cell Viability Assay
| Cell Line: | HTRY-LT cell lines |
| Concentration: | 1-10 μM |
| Incubation Time: | 96 hours |
| Result: | Decreased cell viability by up to 90%. |