1781882-65-2
中文名称
PYRIDOSTATIN HYDROCHLORIDE
英文名称
Pyridostatin hydrochloride
CAS
1781882-65-2
分子式
C5H6ClNSn8
分子量
1065.24
MOL 文件
1781882-65-2.mol
1781882-65-2 结构式
PYRIDOSTATIN HYDROCHLORIDE价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-15176A | PYRIDOSTATIN HYDROCHLORIDE Pyridostatin hydrochloride | 1781882-65-2 | 5mg | 1120元 |
| 2024/04/30 | HY-15176A | PYRIDOSTATIN HYDROCHLORIDE Pyridostatin hydrochloride | 1781882-65-2 | 10mM * 1mLin Water | 1268元 |
| 2024/04/30 | HY-15176A | PYRIDOSTATIN HYDROCHLORIDE Pyridostatin hydrochloride | 1781882-65-2 | 10mg | 1480元 |
常见问题列表
生物活性
Pyridostatin (RR82) hydrochloride 是一种高选择性的 G-quadruplex DNA 稳定剂 (Kd=490 nM)。Pyridostatin hydrochloride 通过诱导复制和转录依赖的 DNA 损伤促进人类癌细胞生长停滞。Pyridostatin hydrochloride 靶向原癌基因 Src。Pyridostatin hydrochloride 降低人乳腺癌细胞 SRC 蛋白水平和 SRC 依赖的细胞运动。靶点
Kd: 490 nM (G-quadruplexe)
体外研究
Pyridostatin (RR82) hydrochloride (10 μM; 48 hours) induces cell cycle arrest.
Pyridostatin hydrochloride is a very selective G-quadruplex DNA-binding small molecule designed to form a complex with and stabilize G-quadruplex structure. Pyridostatin hydrochloride causes neurite retraction, synaptic loss, and dose-dependent neuronal death. In cultured primary neurons, Pyridostatin hydrochloride induces the formation of DNA DSBs. Remarkably, Pyridostatin hydrochloride (1-5 μM, overnight) downregulates the BRCA1 protein, a protein that guards and repairs the neuronal genome, at the transcriptional level.
Cell Viability Assay
| Cell Line: | Over 60 different cancer cell lines |
| Concentration: | 10 μM |
| Incubation Time: | 48 hours |
| Result: | Predominantly accumulated in the G2 phase of the cell cycle over 60 different cancer cell lines. |