193551-21-2

中文名称反式-1-(4-羟基环己基)-4-(4-氟苯基)-5-(2-甲氧基嘧啶-4-基)咪唑

英文名称 SB 239063

CAS 193551-21-2

分子式 C20H21FN4O2

分子量 368.4

MOL 文件 193551-21-2.mol

更新日期 2023/03/20 15:41:27

193551-21-2 结构式

基本信息物理化学性质安全数据图谱信息反式-1-(4-羟基环己基)-4-(4-氟苯基)-5-(2-甲氧基嘧啶-4-基)咪唑价格(试剂级) 常见问题列表

基本信息

中文别名

化合物L-779450
反式-1-(4-羟基环己基)-4-(4-氟苯基)-5-(2-甲氧基嘧啶-4-基)咪唑
反-4-[4-(4-氟苯基)-5-(2-甲氧基-4-嘧啶基)-1H-咪唑-1-基]环己醇
(1R,4R)-REL-4-(4-(4-氟苯基)-5-(2-甲氧基嘧啶-4-基)-1H-咪唑-1-基)环己醇

英文别名

CS-402
SB 239063
SB-239063
SB239063
SB 239063 - CAS 798558-40-4 - Calbiochem
rans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexano
TRANS-1-(4-HYDROXYCYCLOHEXYL)-4-(FLUOROPHENYL)-5-(2-METHOXYPYRIMIDIN-4-YL) IMIDAZOLE
TRANS-4-[4-(4-FLUOROPHENYL)-5-(2-METHOXY-4-PYRIMIDINYL)-1H-IMIDAZOL-1-YL]CYCLOHEXANOL
TRANS-1-(4-HYDROXYCYCLOHEXYL)-4-(4-FLUOROPHENYL)-5-(2-METHOXYPYRIMIDIN-4-YL) IMIDAZOLE
TRANS-1-(4-HYDROXYCYCLOHEXYL)-4-(4-FLUOROPHENYL)-5-(2-METHOXYPYRIDIMIDIN-4-YL)IMIDAZOLE
Cyclohexanol, 4-[4-(4-fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]-, trans-

所属类别

生物化工：激动剂抑制剂

物理化学性质

熔点206-207.2 °C

储存条件2-8°C

溶解度DMSO: 11 mg/mL

溶解度二甲基亚砜：11 毫克/毫升

形态白色固体

颜色white

InChIKeyZQUSFAUAYSEREK-WKILWMFISA-N

安全数据

危险性符号(GHS)

GHS07

警示词警告

危险性描述H302-H315-H319-H335

防范说明P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

安全说明22-24/25

WGK Germany3

RTECS号GV9458000

海关编码2933599590

图谱信息

反式-1-(4-羟基环己基)-4-(4-氟苯基)-5-(2-甲氧基嘧啶-4-基)咪唑(193551-21-2)核磁图(¹HNMR)

反式-1-(4-羟基环己基)-4-(4-氟苯基)-5-(2-甲氧基嘧啶-4-基)咪唑价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-11068	反式-1-(4-羟基环己基)-4-(4-氟苯基)-5-(2-甲氧基嘧啶-4-基)咪唑 SB 239063	193551-21-2	1mg	500元
2024/04/30	HY-11068	反式-1-(4-羟基环己基)-4-(4-氟苯基)-5-(2-甲氧基嘧啶-4-基)咪唑 SB 239063	193551-21-2	10mM * 1mLin DMSO	892元
2024/04/30	B5898	SB 239063 SB 239063	193551-21-2	25mg	970元

常见问题列表

生物活性

SB239063是一种有效的选择性p38 MAPKα/β抑制剂，IC50为44 nM，对γ- 和 δ-激酶亚型没有活性。

靶点

Target	Value
p38α (Cell-free assay)	44 nM
p38β (Cell-free assay)	44 nM

体外研究

SB 239063 (0.1–10 μM ; 29 hours, 47 hours) increases apoptosis of eosinophils in a dose-related in the presence of 10 pM IL-5 at every time point from 21 hours onwards.
SB 239063 potently inhibits IL-1 and TNF- a production in LPS-stimulated human peripheral blood monocytes with IC ₅₀ values of 120 nM and 350 nM, respectively.

Apoptosis Analysis

Cell Line:	Eosinophils (guinea pig BALs)
Concentration:	0.1μM, 1μM, 10μM
Incubation Time:	29 hours, 47 hours
Result:	Increased apoptosis of eosinophils in a dose-related in the presence of 10 pM IL-5 at every time point from 21 hours onwards.

体内研究

SB 239063 (12 mg/kg; p.o.; 1 hour before and 4 hours after OA challenge; b.i.d. for 3 days) significantly inhibits the resultant antigen-induced airway eosinophilia.
SB 239063 (12 mg/kg; p.o.) almost abolishes ovalbumin (OA)-induced airway eosinophilia (~ 93% inhibition) by inhalation.
SB 239063 is a potent inhibitor of LPS-induced TNF-alpha production in the mouse peritoneal cavity with an EC ₅₀ of 5.8 mg/kg (2.8–10.3; 95% CL).

Animal Model:	Male BALB/c mice (18–20 g)
Dosage:	12 mg/kg
Administration:	Oral administration; 1 h before and 4 h after OA challenge; bis in die for 3 days
Result:	Significantly inhibited the resultant antigen-induced airway eosinophilia.