2004-04-8
基本信息
9-(6-脱氧-Β-D-赤式-己-5-烯-2-基呋喃糖基)-9-嘌呤-6-胺
U-7984
decoyinin
DECOYININE
angustmycina
antibiotica14
Decoyinine (U-7984)
Decoyinine [AngustMycin A]
5,6-Psicofuranosenyladenine
Adenosine, 4',5'-didehydro-1'-C-(hydroxymethyl)-
物理化学性质
报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
2024/08/19 | HY-101835 | 德夸菌素 Decoyinine | 2004-04-8 | 1mg | 900元 |
2024/08/19 | HY-101835 | 德夸菌素 Decoyinine | 2004-04-8 | 5mg | 3500元 |
2024/08/19 | HY-101835 | 德夸菌素 Decoyinine | 2004-04-8 | 10 mM * 1 mLin DMSO | 3850元 |
常见问题列表
GMPS.
Decoyinine is an analog of adenosine which causes a decrease in intracellular GTP levels by inhibition of GMP synthetase. Decoyinine exerts a stimulatory effect on oaamylase synthesis only in the strain in which the catabolite repression component of a-amylase regulation has been rendered inoperable by the gra-10 mutation. The apparent stimnulation of a-amylase activity in WLN-11 by Decoyinine is not an artifactual effect exerted at the level of enzyme activity itself. It is observed that purine nucleotides, most notably GMP, exhibits a dramatic inhibitory effect on the activity of Bacillus circulans F-2 amylase and a less-pronounced inhibitory effect on B. subtilis aamylase. At the concentration used in the experiments (1.07 mM), Decoyinine has no effect in vitro on B. subtilis WLN-11 oaamylase activity. At the same concentration, GMP exerts a slight inhibitory effect on aamylase activity.
It is showed that Decoyinine (Angustmycin A) treatment hinders tumor growth in xenograft mouse model. Moreover, like GMPS activity, the effect of Decoyinine does not appear to be subtype specific as it impairs growth of xenografts from cells harboring NRASQ61R (SK-Mel-103) or BRAFV600E (SK-Mel-28) mutations.