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2004-04-8

中文名称 德夸菌素
英文名称 DECOYININE
CAS 2004-04-8
分子式 C11H13N5O4
分子量 279.25
MOL 文件 2004-04-8.mol
更新日期 2024/10/28 15:49:08
2004-04-8 结构式 2004-04-8 结构式

基本信息

中文别名
德夸菌素
9-(6-脱氧-Β-D-赤式-己-5-烯-2-基呋喃糖基)-9-嘌呤-6-胺
英文别名
a14
U-7984
decoyinin
DECOYININE
angustmycina
antibiotica14
Decoyinine (U-7984)
Decoyinine [AngustMycin A]
5,6-Psicofuranosenyladenine
Adenosine, 4',5'-didehydro-1'-C-(hydroxymethyl)-

物理化学性质

熔点198-200℃
沸点639.8±65.0 °C(Predicted)
密度1.87±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度可溶于DMSO
酸度系数(pKa)12.90±0.60(Predicted)
形态结晶固体
颜色White to off-white

安全数据

危险性符号(GHS)GHS hazard pictograms
GHS07
警示词警告
危险性描述H319-H315-H335
危险品标志Xi
危险类别码36/37/38
安全说明26-36
德夸菌素价格(试剂级)
报价日期产品编号产品名称CAS号包装价格
2024/08/19HY-101835德夸菌素
Decoyinine
2004-04-81mg900元
2024/08/19HY-101835德夸菌素
Decoyinine
2004-04-85mg3500元
2024/08/19HY-101835德夸菌素
Decoyinine
2004-04-810 mM * 1 mLin DMSO3850元

常见问题列表

生物活性
Decoyinine 是 GMP 合成酶的一个选择性抑制剂。
靶点

GMPS.

体外研究

Decoyinine is an analog of adenosine which causes a decrease in intracellular GTP levels by inhibition of GMP synthetase. Decoyinine exerts a stimulatory effect on oaamylase synthesis only in the strain in which the catabolite repression component of a-amylase regulation has been rendered inoperable by the gra-10 mutation. The apparent stimnulation of a-amylase activity in WLN-11 by Decoyinine is not an artifactual effect exerted at the level of enzyme activity itself. It is observed that purine nucleotides, most notably GMP, exhibits a dramatic inhibitory effect on the activity of Bacillus circulans F-2 amylase and a less-pronounced inhibitory effect on B. subtilis aamylase. At the concentration used in the experiments (1.07 mM), Decoyinine has no effect in vitro on B. subtilis WLN-11 oaamylase activity. At the same concentration, GMP exerts a slight inhibitory effect on aamylase activity.

体内研究

It is showed that Decoyinine (Angustmycin A) treatment hinders tumor growth in xenograft mouse model. Moreover, like GMPS activity, the effect of Decoyinine does not appear to be subtype specific as it impairs growth of xenografts from cells harboring NRASQ61R (SK-Mel-103) or BRAFV600E (SK-Mel-28) mutations.

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