205640-91-1
基本信息
人OREXIN B
食欲肽B(人) ≥98%
食欲肽B(人) ≥98%, ≥98% (HPLC)
Human orexin B
OREXIN B (HUMAN)
HYPOCRETIN-2, HUMAN
OREXIN B HUMAN ≥98%
PubChem ID: 90479794
OREXINS OREXIN B HUMAN
OREXIN B (HUMAN) USP/EP/BP
Orexin B (human), ≥98% (HPLC)
RSGPPGLQGRLQRLLQASGNHAAGILTM-NH2
物理化学性质
常见问题列表
Ki: 420 nM (OX1), 36 nM (OX2)
Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC 50 of 36 nM in the binding assay and an EC 50 of 60 nM in the [Ca 2+ ]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC 50 in the competitive binding assay and the EC 50 in the [Ca 2+ ]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively.
Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively.