207678-81-7
中文名称
HS014
英文名称
HS014
CAS
207678-81-7
分子式
C71H94N20O17S2
分子量
1563.76
MOL 文件
207678-81-7.mol
更新日期
2024/05/05 20:58:34
207678-81-7 结构式
基本信息
中文别名
N-乙酰基-L-半胱氨酰-L-A-谷氨酰-L-组氨酰-3-(2-萘基)-D-丙氨酰-L-精氨酰-L-色氨酰甘氨酰-L-半胱氨酰-L-脯氨酰-L-脯氨酰-L-赖氨酰-L-A-天冬氨酰胺环(1->8)-二硫醚 英文别名
HS014mc4receptor antagonist
M.W. 1563.77 C71H94N20O17S2
Melanocortin 4 Receptor antagonist
(AC-CYS11,D-2-NAL14,CYS18)-BETA-MSH (11-22) AMIDE
Acetyl-(Cys11,D-2-Nal14,Cys18)-b-MSH (11-22) aMide
Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide
(ACETYL-CYS11-BETA-(2-NAPHTHYL)*-D-ALA14,CYS18)-BET
Acetyl-(Cys11,D-2-Nal14,Cys18)-Beta-MSH (11-22) amide
Acetyl-(Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) aMide HS014
物理化学性质
密度1.57±0.1 g/cm3(Predicted)
储存条件−20°C
储存条件−20°C
酸度系数(pKa)4.07±0.10(Predicted)
形态solid
水溶解性Soluble to 1 mg/ml in water
HS014价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2023/03/20 | HY-P1216 | HS014 HS014 | 207678-81-7 | 1 mg | 4500元 |
| 2023/03/20 | HY-P1216 | HS014 HS014 | 207678-81-7 | 5 mg | 13500元 |
常见问题列表
生物活性
HS014 是一种高效、选择性的黑素皮质素-4 (MC4) 受体拮抗剂，对人 MC4、MC1、MC3 和 MC5 受体的 Ki 值分别为 3.16、108、54.4 和 694 nM。HS014 调节吗啡对小鼠行为的影响。HS014 增加自由喂养大鼠的食物摄取量。体内研究
The dose-effect curve of morphine for locomotor activity was shifted downwards in C57Bl/6 mice pretreated with HS014 and in A(y) mice. The dose-effect curve of morphine for antinociception is shifted two- and threefold to the left in C57Bl/6 mice pretreated with HS014 and in A(y) mice, respectively.
Pretreatment with HS014 blocks the effect of IL-1beta on food intake and respiratory exchange ratio (RER) at later time points (beyond 8 h post injection), as well as the hypoactivity and increases metabolic rate.