22204-24-6
中文名称
双羟萘酸噻嘧啶
英文名称
Pyrantel pamoate
CAS
22204-24-6
分子式
C34H30N2O6S
分子量
594.68
MOL 文件
22204-24-6.mol
更新日期
2024/04/23 09:08:42
22204-24-6 结构式
基本信息
中文别名
(E)-1-甲基-2-[2-(2-噻吩基)乙烯基]-1,4,5,6-四氢嘧啶 4,4'-亚甲基-双(3-羟基2-奈酸)盐双羟萘酸噻嘧啶
双羟乃酸噻嘧啶
恩波酸噻嘧啶
抗虫灵
双羟萘酸喹嘧啶
双羟萘酸噻嘧啶(噻嘧啶)
英文别名
1-METHYL-2-(2-[2-THIENYL]ETHENYL)-1,4,5,6-TETRAHYDROPYRIMIDINE COMPOUND WITH 4,4'-METHYLENEBIS(3-HYDROXY-2-NAPHTHOIC ACID)PYRANTEL PAMOATE
PYRANTEL PAMOATE SALT
PYRANTEL PAMOTE
2-naphthoicacid,4,4’-methylenebis(3-hydroxy-,compd.with(e)-1,4,5,6-tetrahy
antiminth
dro-1-methyl-2-(2-(2-thienyl)vinyl)pyrimidine(1:1)
embovin
pyrantelembonate
1,4,5,6-tetrahydro-1-methyl-2-((E)-2-(2-thienyl)vinyl)pyrimidine 4,4'-methylenebis(3-hydroxy-2-naphthoate)
4,4'-methylenebis(3-hydroxy-2-naphthoic acid) compounded with (E)-1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)vinyl)pyrimidine (1:1)
cobantril
combantrin
cp-10423-16
Dog Wormer
helmex
lombriareu
pirantel pamoate
pyrantel pamoate sigmaultra
trilombrin
所属类别
原料药：驱肠虫药物理化学性质
外观性状黄色至褐色晶体粉末
熔点266-267°C
储存条件0-6°C
溶解度Pratically insoluble in water, soluble in dimethyl sulfoxide, pratically insoluble in methanol.
形态powder
颜色yellow
水溶解性<0.1 g/100 mL at 19 ºC
BRN9034755
BCS Class4
InChIKeyAQXXZDYPVDOQEE-MXDQRGINSA-N
SMILESC(C1=C(C(C(=O)O)=CC2=CC=CC=C12)O)C1=C(C(C(=O)O)=CC2=CC=CC=C12)O.C(/C1=NCCCN1C)=C\C1SC=CC=1
双羟萘酸噻嘧啶价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-12640 | 双羟萘酸噻嘧啶 Pyrantel pamoate | 22204-24-6 | 100mg | 200元 |
| 2024/01/25 | HY-12640 | 双羟萘酸噻嘧啶 Pyrantel pamoate | 22204-24-6 | 10mM * 1mLin DMSO | 220元 |
| 2024/01/25 | HY-12640 | 双羟萘酸噻嘧啶 Pyrantel pamoate | 22204-24-6 | 500mg | 500元 |
常见问题列表
生物活性
Pyrantel pamoate (Pyrantel Embonate)是一种广谱驱虫剂，用于治疗一些寄生虫感染。体外研究
Pyrantel induces
Ascaris suum
muscle contraction, with a pEC
50
of 7.24.
Pyrantel produces spastic paralysis of the nematode by selectively gating acetylcholine receptor ion-channels on nerve and muscle.
Pyrantel (72 h) inhibits the survival of
Ancylostoma ceylanicum
,
Necator americanus
and
Trichuris muris
on the third-stage larvae (IC
50
s=90.9, 2.0, and 95.5 µg/mL, respectively) and adult worms (IC
50
s=>100, 7.6, and 34.1 µg/mL, respectively).
体内研究
Pyrantel (10 mg/kg; a single p.o.) reduces the worms in A. ceylanicum -infected hamsters, with the worm burden reduction of 87.2% and worm expulsion rate of 63.4%.