基本信息
中文别名
西门肺草碱 英文别名
symphytine2-Butenoic acid, 2-methyl-, (1R,7aR)-7-[[(2S,3S)-2,3-dihydroxy-2-(1-methylethyl)-1-oxobutoxy]methyl]-2,3,5,7a-tetrahydro-1H-pyrrolizin-1-yl ester, (2E)-
物理化学性质
沸点508.85°C (rough estimate)
密度1.2168 (rough estimate)
折射率1.5614 (estimate)
酸度系数(pKa)12.59±0.29(Predicted)
(IARC)致癌物分类3 (Vol. 31, Sup 7) 1987
常见问题列表
生物活性
Symphytine 从 Symphytum officinale 中分离出来一种吡啶生物碱，具有致癌性。体内研究
Symphytine (intraperitoneal injection; 13 mg/kg; 330 days) leads to survival for more than 330 days after the start of injections. Four of 20 rats (20%) had liver tumors: three has hemangioendothelial sarcoma and 1 has liver cell adenoma.
| Animal Model: | Male inbred ACI rats |
| Dosage: | 13 mg/kg |
| Administration: | Intraperitoneal injection; 330 days |
| Result: | Led to hepatic tumor in rats. |