28282-25-9
中文名称
BETA-岚香酮酸
英文名称
β-Elemonic Acid
CAS
28282-25-9
分子式
C30H46O3
分子量
454.68
MOL 文件
28282-25-9.mol
更新日期
2024/04/29 17:26:58
28282-25-9 结构式
基本信息
中文别名
Β榄香酮酸Β-榄香酮酸
Β-榄香酮酸
Β-岚香酮酸
Β-榄香酮酸对照品
Β-榄香酮酸标准品
BETA-岚香酮酸
Β-岚香酮酸, 来源于橄榄
Β-ELEMONIC ACID
BETA-岚香酮酸、BETA-榄香酮酸
英文别名
β-ElemonicBeta-EleMonic
β-deMonic acid
β-demonic-acid
B-ELEMONIC ACID
β-Elemonic acid
β-Elemonic acid
Elemadienonic acid
BETA-ELEMONIC ACID
3-Oxotirucallic acid
物理化学性质
外观性状白色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于乳香。
熔点224-225°C
沸点565.2±50.0 °C(Predicted)
密度1.07
储存条件2-8°C
酸度系数(pKa)4.65±0.10(Predicted)
常见问题列表
生物活性
β-Elemonic acid 是从乳香树中分离得到的三萜。β-Elemonic acid 诱导细胞凋亡，活性氧 (ROS) 和 COX-2 表达，并抑制脯氨酰内肽酶。β-Elemonic acid 具有抗癌和抗炎作用。靶点
|
COX-2
|
体外研究
β-elemonic acid (1, 3, 10, 20 µM; 24 hours) strongly induces human A549 lung cancer cell apoptosis in a dose- and time-dependent manner.
β-elemonic acid (1, 3, 10, 20 µM; 24 hours) exerts potent cytotoxic effects on human NSCLC A549 cells in a dose-dependent manner. The IC
50
value following a 24-h exposure to β-elemonic acid was 6.92 µM.
β-elemonic acid (20 µM; 24 hours) results in a cell percentage of 58.01% in the G0/G1 phase.
β-elemonic acid (1, 3, 10, 20 µM; 24 hours) inhibits phosphorylation of p42/44, MAPK/JNK and p38 in the A549 cells.