311309-27-0
311309-27-0 结构式
基本信息
V-8-F-NH2
Rat RFRP-3
V-8-F-NH2, NPVF
H2N-VPNLPQRF-AMIDE
RFamide-related peptide-3
Neuropeptide VF (124-131)
NEUROPEPTIDE VF (124-131) (HUMAN)
RFRP-3 human trifluoroacetate salt
H-VAL-PRO-ASN-LEU-PRO-GLN-ARG-PHE-NH2
物理化学性质
常见问题列表
RFRP-3 efficiently inhibits forskolin-induced production of cAMP with an IC 50 of 0.7 nM. Scatchard-plot analysis shows that 125 I-labelled hRFRP-3 has a single class of high-affinity binding sites for the membrane fractions of CHO cells expressing rat OT7T022, the K d value and the B max values are 0.19 nM and 1.3 pM, respectively.RFRP-3 specifically stimulate cells transfected with a new orphan 7TMR, OT7T022, it binds to OT7T022 as a specific ligand with high affinity (K d = 0.19 nM).RFRP-3 (10 -8 to 10 -14 M) has no effect on LH and FSH levels alone, but when it combines with GnRH, LH and FSH secretion is significantly reduced by the combination.