328232-95-7
328232-95-7 结构式
基本信息
中文别名
反式-N-[1-(2-氟苯基)-1H-吡唑-3-基]-1'-氧代螺[环己烷-1,3'(1'H)-呋喃并[3,4-C]吡啶]-4-甲酰胺 英文别名
MK 0557CS-2471
MK0557
MK 0557
N'-Dicyanomethylene-N-(2,4,5-trichloro-phenyl)-hydrazinecarboxylic acid ethyl ester
N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide
trans-N-[1-(2-Fluorphenyl)-1H-pyrazol-3-yl]-1'-oxospiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide
(1r,4r)-N-(1-(2-fluorophenyl)-1H-pyrazol-3-yl)-1'-oxo-1'H-spiro[cyclohexane-1,3'-furo[3,4-c]pyridine]-4-carboxamide
Spiro[cyclohexane-1,3'(1'H)-furo[3,4-c]pyridine]-4-carboxamide, N-[1-(2-fluorophenyl)-1H-pyrazol-3-yl]-1'-oxo-, trans-
所属类别
生物化工：激动剂抑制剂物理化学性质
熔点240.0-240.6 °C
沸点708.7±60.0 °C(Predicted)
密度1.46±0.1 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 3 mg/ml
酸度系数(pKa)13.40±0.20(Predicted)
形态结晶固体
应用领域
用途1
一种选择性很强的口服神经肽NPY5R拮抗剂,Ki:1.6nM。MK-0557 is a highly selective, orally administered neuropeptide NPY5R antagonist, could limit weight regain after very-low-calorie diet (VLCD)-induced weight loss. Neuropeptide Y (NPY) is a potent orexigenic neuropeptide, and antagonism of NPY Y1 and NPY Y5 receptors (NPYxR) is considered a potentially important anti-obesity drug target.