3947-65-7
中文名称
新霉胺
英文名称
(1'R,3'S,3S,5R,6R)-5-AMINO-2-AMINOMETHYL-6-(4,6-DIAMINO-2,3-DIHYDROXY-CYCLOHEXYLOXY)-TETRAHYDRO-PYRAN-3,4-DIOL
CAS
3947-65-7
分子式
C12H26N4O6
分子量
322.36
MOL 文件
3947-65-7.mol
更新日期
2023/04/06 13:42:47
3947-65-7 结构式
基本信息
中文别名
新霉胺新黴素A
新霉素杂质A
工厂已不再生产
硫酸新霉素杂质 A
新霉素 EP标准品
新霉素杂质A(EP)
硫酸新霉素EP杂质A
硫酸弗雷米锡EP杂质A
硫酸新霉素EP杂质A(NEAMINE)
英文别名
neaminU-5214
C01441
NEAMINE
neomycina
Negamicin
dekamycinv
nebramycinx
Neamine CRS
Framycetin EP Impurity A
所属类别
分析化学：药典标准品和杂质标准品物理化学性质
熔点225.5°C (rough estimate)
比旋光度D25+112.8° (c = 1)
沸点460.98°C (rough estimate)
密度1.1885 (rough estimate)
折射率1.6120 (estimate)
储存条件Hygroscopic, Refrigerator, Under inert atmosphere
溶解度可溶于酸性水溶液轻微）、甲醇（轻微、加热）、水（轻微）
酸度系数(pKa)13.24±0.70(Predicted)
形态neat
颜色白色至淡黄色
稳定性吸湿性
常见问题列表
生物活性
Neamine 是一种 Neomycin 的无毒衍生物，也是一种广谱氨基糖苷类抗生素。Neamine 是靶向血管生成素 (angiogenin) 的抗血管生成剂。Neamine 具有有效的抗菌，抗肿瘤和神经保护活性。体外研究
Neamine (0.625-25 μM; 48 hours; AsPC-1 cells) treatment inhibits ANG-mediated AsPC-1 cell proliferation in a dose-dependent manner in the range of 0.625-25 μM.
Neamine (100 μM) also blocks the nuclear translocation of ANG effectively.
Cell Proliferation Assay
| Cell Line: | AsPC-1 cells |
| Concentration: | 0.625 µM, 1.25 µM, 2.5 µM, 5 µM, 10 µM, 25 µM |
| Incubation Time: | 48 hours |
| Result: | Inhibited angiogenin (ANG)-induced AsPC-1 cells proliferation. |
体内研究
Neamine (30-60 mg/kg; subcutaneous injection; daily; for 14 days; male Balb/c nude mice) has anti-tumor effects on AsPC-1 xenograft models. Neamine reduces the expression levels of ANG, Ki-67 and CD31 in tumor xenografts.
| Animal Model: | Male Balb/c nude mice (4 weeks old) injected with AsPC-1 cells |
| Dosage: | 30 mg/kg, 60 mg/kg |
| Administration: | Subcutaneous injection; daily; for 14 days |
| Result: | Had anti-tumor effects on AsPC-1 xenograft models. |