400827-46-5
中文名称
头孢罗林酯
英文名称
TAK 599
CAS
400827-46-5
分子式
C24H25N8O10PS4
分子量
744.72
MOL 文件
400827-46-5.mol
更新日期
2023/03/20 15:41:25
400827-46-5 结构式
基本信息
中文别名
头孢罗林酯头孢洛林酯杂质
头孢洛林酯乙酸盐
头孢洛林酯杂质对照品
CEFTAROLINE FOSAMIL醋酸盐
英文别名
TAK 599PPI 0903
Ceftaroline fosaMil
C22H22N8O8PS4. C2H3O2
Ceftaroline Fosamil Acetate
TAK-599 (ceftaroline fosamil)
Ceftaroline fosamil acetate salt
TAK-599
CEFTAROLINE FOSAMIL
TAK599
TAK 599
PPI-0903
PPI0903
PPI 0903
所属类别
生物化工：激动剂抑制剂
常见问题列表
生物活性
Ceftaroline fosamil (CX-0903, DSP-5990, PPI-0903, TAK-599, Teflaro, Zinforo) 是一种头孢菌素，对 Gram-positive pathogens (包括耐甲氧西林的金黄色葡萄球菌(MRSA))具有活性。体内研究
Ceftaroline fosamil is effective against all 10 MRSA isolates used in the dose-ranging studies and requires approximately 17 to 43% f T>MIC (the percentage of time that free drug concentrations remain above the MIC) to produce a 1-log 10 kill. The Ceftaroline Fosamil treatment results in mean reductions of 1.1 to 2.4 log 10 CFU, with no relationship to the Ceftaroline Fosamil MIC. The use of high inocula does not affect the Ceftaroline Fosamil efficacy against the three strains tested, with mean decreases of 2.0 to 3.0 log 10 CFU.