41332-24-5
41332-24-5 结构式
基本信息
1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮
1-[4-(二苯基甲基)-1-哌嗪]-3,3-二苯基-1-丙酮
39-1B4
CS-2371
NP 118809
NP118809 (39-1B4
39-1B4
NP-118809
NP 118809
NP118809
1-(DiphenylMethyl)-4-(1-oxo-3,3-diphenylpropyl)piperazine
Piperazine, 1-(diphenylmethyl)-4-(1-oxo-3,3-diphenylpropyl)-
1-[4-(DiphenylMethyl)-1-piperazinyl]-3,3-diphenyl-1-propanone
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-14462 | 1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮 NP118809 | 41332-24-5 | 100mg | 744元 |
| 2024/04/30 | HY-14462 | 1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮 NP118809 | 41332-24-5 | 10mM * 1mLin DMSO | 818元 |
| 2024/04/30 | HY-14462 | 1-【4-(二苯甲基)-1-哌嗪基】-3,3-二苯基-1-丙酮 NP118809 | 41332-24-5 | 200mg | 930元 |
常见问题列表
|
N-Type Ca 2+ Channel 0.11 μM (IC 50 ) |
L-type calcium channel 12.2 μM (IC 50 ) |
NP118809 is a potent N-type calcium channel blocker, with an IC 50 of 0.11 μM; also inhibits L-type calcium channel with an IC 50 of 12.2 μM. NP118809 inhibits the hERG potassium channel in HEK cells, with an IC 50 of 7.4 μM.
NP118809 (25 mg/kg, i.p.) shows significant analgesic activity in the phase IIA portions of the rat formalin model. NP118809 (30 mg/kg, p.o.) results in 80.3% inhibition of mechanical allodynia and 96.3% inhibition of thermal hyperalgesia in the rat spinal nerve ligation model.