5072-26-4
中文名称
丁基硫
英文名称
DL-BUTHIONINE-[S,R]-SULFOXIMINE
CAS
5072-26-4
EINECS 编号
246-685-1
分子式
C8H18N2O3S
MDL 编号
MFCD00070309
分子量
222.31
MOL 文件
5072-26-4.mol
更新日期
2023/03/20 17:41:19
5072-26-4 结构式
基本信息
中文别名
丁基硫丁硫胺酸亚砜胺(BSO)
DL-丁硫氨酸(S,R)-亚砜亚胺
英文别名
DL-BUTHIONINE (R,S)-SULFOXIMINEDL-BUTHIONINE-[S,R]-SULFOXIMINE
DL-BUTHIONINE (S,R)-SULPHOXIME
DL-BUTHIONINE-SULFOXIMINE
2-amino-4-(s-butylsulfonimidoyl)-butanoicaci
2-amino-4-(s-butylsulfonimidoyl)butanoicacid
buthioninesulfoxamine
buthioninesulfoximine
buthioninesulphoximine
butioninesulfoximine
s-(3-amino-3-carboxypropyl)-s-butyl-sulfoximin
Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-.
NSC 381100
S-(3-Amino-3-carboxypropyl)-S-butylsulfoximine
2-Amino-4-(S-butylsulfonimidoyl)butyric acid
所属类别
原料药：抗肿瘤药物理化学性质
熔点215 °C (dec.)(lit.)
沸点382.3±52.0 °C(Predicted)
密度1.29±0.1 g/cm3(Predicted)
储存条件2-8°C
溶解度H2O: 50 mg/mL, clear, colorless
形态蓬松粉末
颜色白色
Merck13,1520
BRN2367136
安全数据
丁基硫价格(试剂级)
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/01/25 | HY-106376 | 丁基硫 DL-Buthionine-(S,R)-sulfoximine | 5072-26-4 | 50mg | 600元 |
| 2024/01/25 | HY-106376 | 丁基硫 DL-Buthionine-(S,R)-sulfoximine | 5072-26-4 | 10mM * 1mLin Water | 660元 |
| 2024/01/16 | C30947 | DL-丁硫氨酸(S,R)-亚砜亚胺 DL-Buthionine (S,R)-sulfoximine, 99% | 5072-26-4 | 500mg | 2107元 |
常见问题列表
生物活性
DL-Buthionine-Sulfoximine (BSO, DL-Buthionine-(S,R)-sulfoximine)是一种 glutathione (GSH) 合成的抑制剂。靶点
| Target | Value |
|
GSH
() |
体外研究
Buthionine sulfoximine is an analogs of methionine sulfoximine and inhibits gamma-glutamylcysteine synthetase about 20 times more effectively than prothionine sulfoximine and at least 100 times more effectively than methionine sulfoximine.
体内研究
Treatment of mice bearing HT1080 and HT1080/DR4 xenografts with a continuous i.v infusion of nontoxic doses of D,L-Buthionine-(S,R)-sulfoximine (300 and 600 mg/kg/day) produce a 60% reduction of GSH plasma levels and greater than 95 % reduction in GSH tumor levels in both parental and multidrug-resistant tumors.