55084-08-7
中文名称
黄芩黄酮II
英文名称
NEOBAICALEIN
CAS
55084-08-7
分子式
C19H18O8
分子量
374.34
MOL 文件
55084-08-7.mol
更新日期
2024/05/07 17:21:34
55084-08-7 结构式
基本信息
中文别名
黄芩新素黄芩黄酮II
黄芩新素II
美黄芩黄酮II
黄芩新素II(美黄芩黄酮II)
英文别名
NEOBAICALEINSkullcapflavone Ⅱ
Skullcapflavon II
SKULLCAPFLAVONE II
scullcapflavone II
Skullcapflavone II >=90% (LC/MS-UV)
2',5-Dihydroxy-6,6',7,8-tetramethoxyflavone
4H-1-Benzopyran-4-one, 5-hydroxy-2-(2-hydroxy-6-methoxyphenyl)-6,7,8-trimethoxy-
物理化学性质
外观性状白色结晶，可溶于甲醇、乙醇、DMSO等有机溶剂，来源于五味子。
沸点636.9±55.0 °C(Predicted)
密度1.375±0.06 g/cm3(Predicted)
溶解度Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
酸度系数(pKa)6.81±0.40(Predicted)
形态粉末
颜色黄色
常见问题列表
黄芩
黄芩为唇形科多年生草本。其有效成分为黄芩素、黄芩甙、汉黄芩素、黄芩新素等5种黄酮成分。此外，还含有β-谷甾醇、苯甲酸、黄芩酶等。有抑菌、抗病毒、镇静、利尿、保肝、保胆、解毒、消炎及使血糖上升等作用。主要用于治疗烂鳃病、疖疮病、打印病、出血性败血症、肠炎病等。生物活性
Skullcapflavone II 是从黄芩中提取的黄酮类化合物，具有抗炎、抗菌作用。Skullcapflavone II 调节破骨细胞的分化、存活和功能。Skullcapflavone II 对 M. aurum 和M. bovis BCG 具有较强的抗菌活性。体外研究
Skullcapflavone II inhibits osteoclastogenesis with decreased activation of MAPKs, Src, and cAMP response element-binding protein (CREB), which have been known to be redox sensitive. Skullcapflavone II decreases reactive oxygen species by scavenging them or activating nuclear factor-erythroid 2-related factor 2 (Nrf2), and its effects were partially reversed by hydrogen peroxide cotreatment or Nrf2 deficiency.
体内研究
Skullcapflavone II, a potential bradykinin antagonist, reduces the major pathophysiological features of allergic asthma, at least in part by acting on TGF-β1/Smad signaling pathways.