58337-38-5
中文名称
EHNA
英文名称
erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride
CAS
58337-38-5
分子式
C14H24ClN5O
分子量
313.826
MOL 文件
58337-38-5.mol
58337-38-5 结构式
基本信息
中文别名
外消旋-9-(2-羟基-3-壬基)腺嘌呤盐酸盐 英文别名
rac erythro-9-(2-Hydroxy-3-nonyl)adenine Hydrochloride Salterythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride
erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride
常见问题列表
生物活性
EHNA hydrochloride 是一个强有力的和选择性的环核苷酸磷酸二酯酶 2 (PDE2) (IC50=4 μM) 和腺苷脱氨酶 (ADA) 的双重抑制剂。EHNA hydrochloride 浓度依耐性抑制 cGMP 刺激的 PDE2 的活性，IC50 值分别为 0.8 μM (人类) 和 2 μM (猪心肌)，但是对没有刺激的 PDE2 抑制力较小。EHNA hydrochloride 在调节多种药理反应中发挥作用，包括抗病毒、抗肿瘤和抗心律失常作用。靶点
|
hPDE2A 0.8 μM (IC 50 ) |
体外研究
EHNA completely ablates the ability of cyclic GMP to activate PDE2 activity, whilst having a much smaller inhibitory effect on the unstimulated PDE2 activity.EHNA exhibits normal Michaelian kinetics of inhibition for the cyclic GMP-stimulated PDE2 activity with Hill plots near unity.EHNA prevents dAdo degradation and increases mitochondrial dATP levels in fibroblasts.