6061-96-7
6061-96-7 结构式
基本信息
(±)-2-甲基柠檬酸[干冰运输]
2-METHYLCITRIC ACID
DL-2-METHYLCITRIC ACID
YNOXCRMFGMSKIJ-UHFFFAOYSA-N
2-Methylcitric Acid (unlabelled)
2-hydroxybutane-1,2,3-tricarboxylic acid
1,2,3-Butanetricarboxylic acid, 2-hydroxy-
2-Hydroxy-3-methyl-1,2,3-propanetricarboxylic acid
2-Methylcitric Acid (mixture of diastereomers) (unlabelled)
物理化学性质
常见问题列表
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Human Endogenous Metabolite
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2-Methylcitric acid (Methylcitric acid) impairs glutamate metabolism and induces permeability transition in brain mitochondria. 2-Methylcitric acid inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM.
2-Methylcitric acid (1-3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca
2+
-loaded mitochondria supported by different substrates.
2-Methylcitric acid behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis. 2-Methylcitric acid does not significantly impair mitochondrial glutamate transport. 2-Methylcitric acid does not significantly impair glutamate mitochondrial transport in liver mitochondria.