64748-79-4
中文名称
阿珠莫林
英文名称
Azumolene
CAS
64748-79-4
分子式
C13H9BrN4O3
分子量
349.14
MOL 文件
64748-79-4.mol
更新日期
2024/10/25 16:41:16
64748-79-4 结构式
基本信息
中文别名
阿珠莫林 英文别名
Azumolene1-[[[5-(4-Bromophenyl)-2-oxazolyl]methylene]amino]hydantoin
2,4-Imidazolidinedione, 1-[[[5-(4-bromophenyl)-2-oxazolyl]methylene]amino]-
常见问题列表
生物活性
Azumolene (EU4093 free base)，一种 Dantrolene 的类似物，是一种肌肉松弛剂。Azumolene 是一种 ryanodine 受体 (ryanodine receptor (RyR)) 调节剂，并通过 ryanodine 受体抑制钙释放。Azumolene 可用于恶性高热研究。体外研究
Pretreatment with 20 µM Azumolene for 1-2 min inhibits SOCE activated by subsequent addition of caffeine and ryanodine to promote RyR-dependent sarcoplasmic reticulum Ca 2+ store depletion in mouse myotubes and adult muscle fibers.
体内研究
The effect of Azumolene (EU4093) on the twitch of the intact rat soleus preparation is nearly maximal at a dose of 20 mg/kg. This dose of Azumolene reduces the amplitude of the twitch to 31.9% of the control value. The contraction of intrafusal muscle as measured by the response of spindle afferent discharge is also reduced by Azumolene.