67884-30-4
中文名称
石斛酚
英文名称
Dendrophenol
CAS
67884-30-4
分子式
C16H18O4
分子量
274.31
MOL 文件
67884-30-4.mol
更新日期
2024/05/06 18:28:24
67884-30-4 结构式
基本信息
中文别名
石斛酚标准品 英文别名
Phenol, 5-[2-(3-hydroxy-5-methoxyphenyl)ethyl]-2-methoxy-Gigantol ( 5-[2-(3-Hydroxy-5-methoxyphenyl)ethyl]-2-methoxyphenol)
所属类别
生物化工：抑制剂物理化学性质
外观性状类白色结晶体，易溶于甲醇、乙酸乙酯，几乎不溶于水，来源于金钗石斛。
沸点454.1±40.0 °C(Predicted)
密度1.204±0.06 g/cm3(Predicted)
储存条件-20°C储存
溶解度DMSO : ≥ 160 mg/mL (583.28 mM)
酸度系数(pKa)9.63±0.10(Predicted)
常见问题列表
生物活性
Gigantol是一种来自几种药用兰花的联苄基化合物。 Gigantol 具有抗肿瘤活性。Gigantol 是 Wnt/β-catenin 通路的抑制剂。靶点
Wnt
体外研究
Gigantol decreases the level of phosphorylated LRP6 and cytosolic β-catenin in HEK293 cells. In breast cancer MDA-MB-231 and MDA-MB-468 cells, treatment with gigantol reduces the level of phosphorylated LRP6. Gigantol significantly inhibits the proliferation and induces apoptosis of the HepG2 cells. Gigantol at concentrations of 1, 40 and 150 µM markedly decreases the cell viability by 11.7, 30.0 and 56.4% at 24 h and 21.1, 66.8 and 85.5% at 48 h, respectively. The IC 50 value is 9.30 µM.
体内研究
LDD and gigantol (25–100 mg/kg, p.o.) significantly increase the hot-plate latency in comparison to vehicle-treated mice and decreased carrageenaninduced inflammation in rats.