72873-74-6

中文名称 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑

英文名称 6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDINYL)IMIDAZO[2,1-B]THIAZOLE DIHYDROCHLORIDE

CAS 72873-74-6

分子式 C16H12FN3S

分子量 297.35

MOL 文件 72873-74-6.mol

更新日期 2023/10/26 17:11:16

72873-74-6 结构式

基本信息物理化学性质安全数据图谱信息 6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑价格(试剂级) 常见问题列表

基本信息

中文别名

6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑

英文别名

CS-1711
SKF-86002
SKF 86002
SKF86002
SKF 86002 DIHYDROCHLORIDE
SKF-86002 - CAS 72873-74-6 - Calbiochem
6-(4-fluorophenyl)-5-(pyridin-4-yl)-2,3-dihydroiMidazo[2,1-b]thi
5-(4-Pyridyl)-6-(4-fluorophenyl)-2,3-dihydroimidazo[2,1-b]thiazole
6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PYRIDYL)IMIDAZO[2,1-B]THIAZOLE
6-(4-FLUOROPHENYL)-2,3-DIHYDRO-5-(4-PRIDYL)IMIDAZO-[2,1,B]-THAIZOLE
6-(4-FLUOROPHENYL)-5-(4-PYRIDYL)-2,3-DIHYDROIMIDAZO[2,1-B]-THIAZOLE

所属类别

生物化工：激动剂抑制剂

物理化学性质

熔点189-190 °C(lit.)

沸点476.1±55.0 °C(Predicted)

密度1.39±0.1 g/cm3(Predicted)

储存条件Keep in dark place,Sealed in dry,2-8°C

溶解度DMSO: 9 mg/mL, soluble

酸度系数(pKa)4.36±0.10(Predicted)

形态solid

颜色off-white

InChIKeyYOELZIQOLWZLQC-UHFFFAOYSA-N

安全数据

危险性符号(GHS)

GHS06

警示词危险

危险性描述H301+H311+H331-H315-H319-H227

防范说明P501-P261-P270-P210-P271-P264-P280-P370+P378-P337+P313-P305+P351+P338-P361+P364-P332+P313-P301+P310+P330-P302+P352+P312-P304+P340+P311-P403+P233-P403+P235-P405

危险品标志Xi

危险类别码36/37/38

安全说明26-36

WGK Germany3

海关编码2934999090

图谱信息

6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑(72873-74-6)核磁图(¹HNMR)

6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑价格(试剂级)

报价日期	产品编号	产品名称	CAS号	包装	价格
2024/04/30	HY-12511	6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑 SKF-86002	72873-74-6	2mg	400元
2024/04/30	HY-12511	6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑 SKF-86002	72873-74-6	5 mg	810元
2024/04/30	HY-12511	6-(4-氟苯基)-5-(4-吡啶基)-2,3-二氢咪唑并[2,1-B]-噻唑 SKF-86002	72873-74-6	10mM * 1mLin DMSO	891元

常见问题列表

生物活性

SKF-86002 是一种具有口服活性的 p38 MAPK 抑制剂，具有抗炎、抗关节炎和镇痛活性。SKF-86002 能抑制脂氧合酶和环氧合酶介导的花生四烯酸代谢。

体外研究

SKF-86002 (10 μM; 1 hour) inhibits apoptosis induced by stress stimulation with UV irradiation (UV).
SKF-86002 does not inhibit UV-induced apoptosis in undifferentiated HL-60 cells.
SKF-86002 (10 μM; 72 hours) prevent IL-4-induced monocyte or U937 cell CD23 surface expression and protein formation with no effect on CD23 mRNA levels.

Western Blot Analysis

Cell Line:	U937 cells
Concentration:	10 μM
Incubation Time:	72 hours
Result:	Significantly reduced CD23 levels on IL-4-treated U937 cells.

体内研究

SKF-86002 (10-90 mg/kg; p.o.; daily; for 22 days) has antiarthritic activity.

Animal Model:	Lewis rats, with adjuvant-induced arthritis (AA)
Dosage:	10 mg/kg, 30 mg/kg, 90 mg/kg
Administration:	Oral administration, daily, for 22 days
Result:	Significantly decreased hindleg volumes after injection of adjuvant.