78441-82-4

中文名称 BMY-25271

英文名称 N-[2-[[[5-[(Dimethylamino)methyl]furan-2-yl]methyl]thio]ethyl]-1,2,5-thiadiazole-3,4-diamine1-oxide

CAS 78441-82-4

分子式 C12H19N5O2S2

分子量 329.44

MOL 文件 78441-82-4.mol

78441-82-4 结构式

基本信息物理化学性质常见问题列表

基本信息

中文别名

化合物 T10575

英文别名

BMY-25271
N-[2-[[[5-[(Dimethylamino)methyl]furan-2-yl]methyl]thio]ethyl]-1,2,5-thiadiazole-3,4-diamine1-oxide
1,2,5-Thiadiazole-3,4-diamine, N3-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-, 1-oxide

物理化学性质

储存条件-20°C储存

溶解度溶于二甲基亚砜

常见问题列表

生物活性

BMY-25271 是一个组胺 H2 受体 (histamine H2 receptor) 拮抗剂。

靶点

Histamine H2 receptor

体内研究

BMY-25271 is a histamine H2 receptor antagonist. The dose response curves are parallel and oral ED ₅₀ values derived from probit analysis are 0.093, 0.97 and 6.9 mg/kg for BMY-25271, ranitidine and cimetidine, respectively. BMY-25271, therefore, is about 10 and 74 times more potent than ranitidine and cimetidine, respectively. Pretreatment with the highest dose of BMY-25271 does not significantly affect the absorption of aspirin or the formation of its major metabolite, salicylic acid.