88847-89-6
中文名称
8-OH-脱氧鸟嘌呤
英文名称
8-OXO-2'-DEOXYGUANOSINE
CAS
88847-89-6
分子式
C10H13N5O5
分子量
283.24
MOL 文件
88847-89-6.mol
更新日期
2023/09/01 14:50:13
88847-89-6 结构式
基本信息
中文别名
8-羟基脱氧鸟苷8-OH-脱氧鸟嘌呤
8-羟基-2-脱氧鸟苷
2'-脱氧-8-氧代鸟嘌呤
8-羟基-2'-脱氧鸟嘌呤
2'-脱氧-7,8-二氢-8-氧代鸟苷
英文别名
8-Oxodeoxyguanosine2-Amino-9-((2R,4S,5R)
-3H-purine-6,8(7H,9H)
8-hydroxydeoxyguanosine
8-OXO-2'-DEOXYGUANOSINE
2'-Deoxy-8-oxoguanosine
2'-Deoxy-8-oxo-D-guanosine
8-HYDROXY-2'-DEOXYGUANOSINE
8-oxo-7-hydrodeoxyguanosine
2'-Deoxy-8-hydroxyguanosine
所属类别
生物化工：脱氧核苷酸及其类似物物理化学性质
熔点217-220°C
密度2.25±0.1 g/cm3(Predicted)
储存条件2-8°C
溶解度溶于DMSO（高达10mg/ml）。
酸度系数(pKa)7.86±0.20(Predicted)
形态白色至类白色固体
颜色米白色
稳定性DMSO中的溶液可在-20°下稳定储存1个月。
常见问题列表
生物活性
8-Hydroxy-2'-deoxyguanosine 是氧化应激和致癌反应的关键生物标志物。靶点
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Human Endogenous Metabolite
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体外研究
8-Hydroxy-2'-deoxyguanosine (8-OHdG) is a good biomarker for risk assessment of various cancers and degenerative diseases. The biomarker 8-Hydroxy-2'-deoxyguanosine (8-OHdG) or 8-oxodG has been a pivotal marker for measuring the effect of endogenous oxidative damage to DNA and as a factor of initiation and promotion of carcinogenesis. The biomarker has been used to estimate the DNA damage in humans after exposure to cancer-causing agents, such as tobacco smoke, asbestos fibers, heavy metals, and polycyclic aromatic hydrocarbons.