磷酸哌喹
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- CAS号:
- 85547-56-4
- 英文名:
- 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate
- 英文别名:
- Pipraquine Phosphate;PIPERAQUINE PHOSPHATE;antimalarial drugs PIPERAQUINE PHOSPHATE;2-(9-methyldecyl)-5-(4-methylpentyl)benzene-1,3-diol;4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline);4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate;4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate;Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-, phosphate;4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate USP/EP/BP;Piperaquine PhosphateQ: What is
Piperaquine Phosphate Q: What is the CAS Number of
Piperaquine Phosphate Q: What is the storage condition of
Piperaquine Phosphate Q: What are the applications of
Piperaquine Phosphate
- 中文名:
- 磷酸哌喹
- 中文别名:
- 磷酸喹哌;磷酸哌喹;哌喹磷酸盐;1,3-双[4-(7-氯-喹啉-4-基)哌嗪-1-基]丙烷磷酸盐
- CBNumber:
- CB02131090
- 分子式:
- C29H32Cl2N6.H3PO4
- 分子量:
- 633.51
- MOL File:
- 85547-56-4.mol
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磷酸哌喹化学性质
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储存条件:
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Store at -20°C
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溶解度:
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DMSO: Insoluble;
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水溶解性:
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Water: 2 mg/mL (3.16 mM)
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磷酸哌喹性质、用途与生产工艺
Piperaquine phosphate 是一种双喹啉抗疟药，可以与青蒿素联用于抗疟研究。
Piperaquine (10-90 mg/kg; a single i.p.) decreases parasitemia at all of the doses tested in mice.
Piperaquine (90 mg/kg; a single i.p.) exhibits the t
1/2
, apparent clearance, and apparent volume of distribution 17.8 days, 33.5 mg•h/L, 1.55 L/h/kg, and 956 L/kg, respectively, in healthy mice and 16.1 days, 27.3 mg•h/L, 1.9 L/h/kg, and 1,059 L/kg in malaria-infected mice.
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Animal Model:
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Male BALB/c mice (7 to 8 weeks) are inoculated with
Plasmodium berghei
parasites
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Dosage:
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0, 10, 30, 90 mg/kg
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Administration:
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A single i.p. administration
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Result:
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The median survival time was 10 days at dose of 10 mg/kg.
The median survival time was 54 days at dose of 30 mg/kg.
All mice were active and alert and had stable body weights throughout the course of the study at dose of 90 mg/kg.
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Animal Model:
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Male Swiss mice (6 weeks old)
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Dosage:
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90 mg/kg (Pharmacokinetic Analysis)
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Administration:
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A single i.p. administration
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Result:
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t
1/2
=17.8 d; AUC=33.5 mg•h/L; apparent clearance=1.55 L/h/kg; apparent volume of distribution=956 L/kg.
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磷酸哌喹
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
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| 2024/01/25 | HY-B1896A | Piperaquine phosphate | | 5 mg | 650元 |
| 2024/01/25 | HY-B1896A | Piperaquine phosphate | | 10 mg | 1100元 |
85547-56-4, 磷酸哌喹 相关搜索:
- 药靶配体
- 生物医药-医药原料
- 化学试剂
- 医用原料
- 科研试剂
- 医药原料
- 原料
- 医药中间体
- 原料药
- C29H35Cl2N6O4P
- 哌喹磷酸盐
- 磷酸喹哌
- 1,3-双[4-(7-氯-喹啉-4-基)哌嗪-1-基]丙烷磷酸盐
- 磷酸哌喹
- 85547-56-4
- 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate
- Pipraquine Phosphate
- Piperaquine PhosphateQ: What is
Piperaquine Phosphate Q: What is the CAS Number of
Piperaquine Phosphate Q: What is the storage condition of
Piperaquine Phosphate Q: What are the applications of
Piperaquine Phosphate
- 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate USP/EP/BP
- 2-(9-methyldecyl)-5-(4-methylpentyl)benzene-1,3-diol
- antimalarial drugs PIPERAQUINE PHOSPHATE
- 4,4'-(1,3-Propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline)
- Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-, phosphate
- PIPERAQUINE PHOSPHATE
- 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloroquinoline) phosphate